Detail of "25953-19-9"

Reference

Pelvic tissue and serum concentrations of various antibiotics given as pre-operative medication

Pelvic tissue and serum concentrations of various antibiotics given as pre-operative medication. Elder, M. G.; Bywater, M. J.; Reeves, D. S. (Dep. Obstet. Gynaecol., Charing Cross Hosp. Med. Sch., London, Engl.). Br. J. Obstet. Gynaecol., 84(12), 887-93 (English) 1977. CODEN: BJOGAS. ISSN: 0306-5456. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 14 Talampicillin [47747-56-8], cephalexin [15686-71-2], and clindamycin [18323-44-9] were administered orally, and ampicillin [69-53-4], cephazolin [25953-19-9], clindamycin and spectinomycin [1695-77-8] i.m. as preoperative medication to women who were having an abdominal hysterectomy. Antibiotic levels in serum, myometrium or cervix, and fallopian tube were estd. Antibiotic absorption from the gastrointestinal tract was delayed, but i.m. therapy produced serum levels compatible with those reported in ambulant volunteers. None of the antibiotics produced a concn. which inhibited all the potential pathogens causing pelvic inflammatory disease. Inhibitory concns. were produced by cephazolin except against bacteroides; by clindamycin except against enterobacteria; by ampicillin except against bacteroides and enterobacteria; and by spectinomycin except against resistant strains of streptococci. The need for a reassessment of dose regimens and route of administration as well as the possible need for using 2 antibiotics together for the treatment of pelvic inflammatory disease is suggested.

Suppression of lymphocyte responses by cephalosporins

Suppression of lymphocyte responses by cephalosporins. Chaperon, E. A.; Sanders, W. E., Jr. (Dep. Med. Microbiol., Creighton Univ., Omaha, Nebr., USA). Infect. Immun., 19(2), 378-84 (English) 1978. CODEN: INFIBR. ISSN: 0019-9567. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Human peripheral blood lymphocytes were cultured in the presence of several cephalosporins. Suppression of responses to phytohemagglutinin and concanavalin A were seen in cultures contg. 50 mg cephalothin (I) [153-61-7], cephalexin [15686-71-2], or cephradine [38821-53-3]/mL. Lymphocyte responses to pokeweed mitogen were suppressed by 50 mg cephalexin, cephradine, or cefoxitin [35607-66-0]/mL. A higher concn. (100 mg/mL) of all cephalosporins except cefoxitin and cefazolin [25953-19-9] suppressed the phytohemagglutinin response to < 20% that of controls. Chloramphenicol [56-75-7] (50 mg/mL) did not inhibit the response to any mitogen used. Apparently, cephalosporins should not be used for prevention of bacterial overgrowth in certain cell cultures. Since many of the cephalosporins were suppressive in therapeutically attainable concns., these results may have potential clin. significance.