Detail of "25999-31-9"

Reference

The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells

The mechanism of histamine release induced by the ionophore X537A from isolated rat mast cells. I. Significance of monovalent cations, calcium, metabolic energy and temperature. Kazimierczak, W.; Patkar, S. A.; Diamant, B. (Dep. Pharmacol., Univ. Copenhagen, Copenhagen, Den.). Acta Physiol. Scand., 102(3), 265-73 (English) 1978. CODEN: APSCAX. ISSN: 0001-6772. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Histamine [51-45-6] release induced by X537A [25999-31-9] from isolated rat mast cells was dependent on the presence of Na or K but not on Ca in the incubation medium. The rate of release was faster in the presence of K than in the presence of Na, but the final release was the same after prolonged incubation. Extracellular Ca as well as metabolic inhibitors depressed the rate of release induced by X537A. Pretreatment of mast cells with either EDTA or the ionophore A23187 in the absence of extracellular Ca did not influence subsequent release induced by X537A. The findings of release at 45° and lack of release at 0° distinguish the mechanism of action of X537A from Ca- and energy-dependent releasing agents like compd. 48/80 and A23187 on the 1 hand and the simple lytic action of decylamine on the other.

Acquired immunity to Eimeria tenella in lasalocid-treated chickens

Acquired immunity to Eimeria tenella in lasalocid-treated chickens. Sasmal, N. K.; Sinha, P. K.; Senapati, P. K.; Bhowmik, M. K. (Dep. Vet. Parasitol., Bidhan Chandra Agric. Univ., Nadia 741 246, India). Vet. Parasitol., 15(1), 1-9 (English) 1984. CODEN: VPARDI. ISSN: 0304-4017. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In chickens with exptl. E. tenella infestation and given lasalocid [25999-31-9] (125 ppm in the feed) starting at different periods, coccidial lesions were very low when medication was started 1 day before or on the day of infestation and were higher when it was started on days 1 or 2 after infestation. When the medication was delayed until day 3 or 4, lesion scores were very high. On the other hand, when the birds were given a challenge inoculation of Eimeria on day 14 after the 1st (immunizing) inoculation, the highest lesions occurred in the groups given the early medication, indicating partial interference with the development of immunity. Lesion scores gradually declined as treatment was delayed. There was a correlation between day of treatment, the lesion score, and the wt. gain of the cecum and spleen. After both the immunizing and challenge infestations, the bursa did not show any variation in wt., whereas the wt. of the spleen did vary. The infested, unmedicated group and the delayed-treatment groups had a comparatively higher splenic wt. than the uninfested, unmedicated group of birds. After immunization, the cecal wt. increased in the delayed-treatment groups, but after challenge there was no difference among the groups. Thus, the cecal wt. showed a direct relation with lesion score.