Reference

Thermogravimetric analysis of calcium and disodium fosfomycin

Thermogravimetric analysis of calcium and disodium fosfomycin. Analytical application for purity control. Tomassetti, Mauro; Campanella, Luigi; Cignini, Pierluigi; D'Ascenzo, Guiseppe (Dip. Chim., Univ. Rome "La Sapienza", Rome, Italy). Thermochim. Acta, 84, 295-308 (English) 1985. CODEN: THACAS. ISSN: 0040-6031. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Thermogravimetric analyses in O, N, and static air between 20 and 1000° and DSC analyses in static air between 20 and 500° of the Ca salt [26016-98-8] and di-Na salt [26016-99-9] of fosfomycin [23155-02-4] were performed. The main decompn. processes were examd. and the thermogravimetric residues analyzed by IR and X-ray powder spectra, and were constituted by the resp. pyrophosphates, which are thermally very stable. Evaluation of the purity of the initial compd. was performed on these residues, based on the comparison between the theor. and the exptl. Na and Ca percentages found in the final residue. Satisfactory values of precision (relative std. deviation <1%) and accuracy (<1%) were obtained. In the case of di-Na fosfomycin, succinic acid [110-15-6] had to be added, to obtain reliable results.

Pharmacokinetic study of fosfomycin and its bioavailability

Pharmacokinetic study of fosfomycin and its bioavailability. Cadorniga, R.; Diaz Fierros, M.; Olay, T. (Fac. Farm., Madrid, Spain). Chemotherapy (Basel), 23, Suppl. 1(Fosfomycin, Proc. Int. Symp., 1975), 159-74 (English) 1977. CODEN: CHTHBK.There are some reagents with their cas registry numbers 26016-98-8 and 26016-99-9 are used in this study. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The pharmacokinetics of fosfomycin (I) was studied in 6 young healthy volunteers after i.v. administration of 500 mg disodium fosfomycin [26016-99-9] and after oral administration of the same dose of calcium fosfomycin [26016-98-8] in 3 different formulations. It was proven that I follows a bicompartmental pattern, for which the disposition consts., the biol. half-lives for the fast and slow phases, and the distribution consts. were calcd. The renal excretion const. was evaluated making detns. of I in the urine, and this const. together with the elimination consts. allowed the detn. of extrarenal elimination. The concn. and quantity of the drug in the central and peripheral compartments were calcd. and tabulated for different periods of time. An analogous behavior was obtained with the 3 formulations that were orally administered, with an av. bioavailability of 37% in relation to the intravenous bioavailability, as evaluated by means of the accumulative renal excretion. .