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Detail of "26095-59-0"

  • CAS Number:
  • 26095-59-0
  • Name:
  • Otilonium bromide

  • Molecular Structure:
  • Formula:
  • C29H43BrN2O4
  • Molecular Weight:
  • 563.65
  • Synonyms:
  • Ethanaminium,N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide(1:1);Ammonium,diethyl(2-hydroxyethyl)methyl-, bromide, p-[o-(octyloxy)benzamido]benzoate(8CI);Benzoic acid, p-[o-(octyloxy)benzamido]-, ester withdiethyl(2-hydroxyethyl)methylammonium bromide (8CI);Otiloniumbromide;SP 63;Spasmomen;
  • EINECS:
  • 247-457-4
  • Melting Point:
  • 130-133 °C
  • Appearance:
  • white power

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CAS No.26095-59-0 Otilonium bromideCompetitive Product

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CAS No.26095-59-0 Otilonium bromide

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CAS No.26095-59-0 Otilonium bromide

Assay:≥ 98.5%  Appearance:white to whi...

Chemical name:Otilonium bromide Structural formula: Molecular formula:C29H43BrN2O4; Molecular weight:563.57 Loss on drying:≤ 0.5% ; Residue on ignition:≤ 0.2% ; Heavy metal:≤ 20ppm ; Single contaminant:≤ 0.5% ; Miscellaneous:≤ 1.0% ;

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CAS No.26095-59-0 Otilonium Bromide

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CAS No.26095-59-0 Otilonium bromide

Otilonium bromide 26095-59-0 Synonyms Octylonium bromide; Diethyl(2-hydroxyethyl) methylammonium bromide p-(o-(octyloxy)benzamido)-benzoate; N,N-Diethyl-N-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)oxy)-ethanaminium bromide Molecular Formula C29H43N2O4.Br Molec

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CAS No.26095-59-0 Otilonium bromide

Otilonium Bromide CAS NO.:26095-59-0

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CAS No.26095-59-0 Otilonium bromide

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CAS No.26095-59-0 Otilonium bromide

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CAS No.26095-59-0 Otilonium bromide

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Otilonium Bromide

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Otilonium bromide

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Reference

A study of the absorption of octylonium bromide following oral administration in man
A study of the absorption of octylonium bromide following oral administration in man. Signorini, C.; Tosoni, S.; Ballerini, R.; Chinol, M.; Mannucci, C. (Fac. Med., Inst. Chem., Brescia, Italy). Drugs Exp. Clin. Res., 10(4), 273-6 (English) 1984. CODEN: DECRDP. ISSN: 0378-6501. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A sensitive method (10 mg/L) for the detn. of octylonium bromide (I) [26095-59-0] in plasma is described. Plasma samples from healthy volunteers following oral administration of octylonium bromide (40 mg) were analyzed by gas chromatog./mass fragmentog. Under the exptl. conditions described, no plasma concns. of octylonium bromide higher than 10 mg/L were found.
System and organ-selectivity of smooth muscle relaxants on in vitro spontaneously contracting preparations
System and organ-selectivity of smooth muscle relaxants on in vitro spontaneously contracting preparations. Manzini, S.; Maggi, C. A.; Meli, A. (Pharmacol. Dep., A. Menarini Pharm., Florence 50131, Italy). Arch. Int. Pharmacodyn. Ther., 270(1), 50-60 (English) 1984. CODEN: AIPTAK. ISSN: 0003-9780. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of verapamil [52-53-9], papaverine [58-74-2], and octylonium bromide [26095-59-0] on amplitude and frequency of spontaneous contractions of rabbit duodenum and rat colon, portal vein, and right atria were investigated. Myogenic nature of spontaneous contractions was demonstrated by their resistance to tetrodotoxin and hexamethonium. Verapamil reduced, in a concn.-dependent manner, amplitude and frequency of spontaneous contractions with a certain degree of selectivity for duodenal prepns. Automaticity of rat atria was affected by concns. of verapamil higher than those required to modify automaticity of intestinal prepns. Papaverine , was almost equipotent in reducing the amplitude of spontaneous contractions of each prepn. but inhibited the frequency of contractions in the following order: colon > duodenum > atrium. Octylonium bromide was characterized by its greater effectiveness in reducing frequency and amplitude of spontaneous contractions of rat colon as compared to the other prepns. All 3 smooth muscle relaxant drugs, in spite of concn.-related redn. in amplitude, caused a parallel enhancement of frequency of spontaneous contractions in rat portal vein. Differences in drug selectivity are discussed in terms of different roles played by various Ca++-dependent processes (which constitute he cellular target of action of these smooth muscle relaxant drugs) in the genesis of frequency and amplitude of myogenic contractions in the various prepns.
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