Reference

Dichloromethane as an Unusual Methylene Equivalent

Dichloromethane as an Unusual Methylene Equivalent. A New Entry of Highly Nucleophilic and Selective Titanium-Methylene Complexes for Ester Methylenation. Yan, Tu-Hsin; Chien, Ching-Ting; Tsai, Chia-Chung; Lin, Kuo-Wei; Wu, Yen-Hsien (Department of Chemistry, National Chung-Hsing University, Taichung 400, Taiwan). Organic Letters, 6(26), 4965-4967 (English) 2004 American Chemical Society. CODEN: ORLEF7. ISSN: 1523-7060. DOCUMENT TYPE: Journal CA Section: 21 (General Organic Chemistry) Section cross-reference(s): 45 The successful application of CH2Cl2-Mg-TiCl4-system mediated methylenation of various esters such as tert-Bu ester and 2,5-cyclohexadiene-1-carboxylate highlights the extraordinary reactivity, selectivity, and the nonbasic nature of this new methylene-carbenoid, which serves as a practical reagent applicable to large-scale synthesis. E.g., methylenation of PhCH2CO2Et by CH2Cl2-Mg-TiCl4 gave 90% PhCH2C(:CH2)OEt.Except for chemicals metioned above, 827615-85-0 and 26537-19-9 are also used. .