Detail of "2667-89-2"

Reference

Studies on clinical pharmacy

Studies on clinical pharmacy. VII.Several substances are used for example 137-76-8 and 137-86-0 which are their cas registry numbers. Recovery of vitamin B1 from many kinds of vitamin B1 derivatives. Satake, Kenzo; Zaitsu, Naotoshi (Kumamoto Univ. Hosp., Kumamoto, Japan). Kyushu Yakugakkai Kaiho, 29, 83-90 (Japanese) 1975. CODEN: KYYKBN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Vitamin B1 derivs. (50 mg as tablets) were given orally to healthy human subjects and excretion rates for 7 hr. were detd. as vitamin B1-HCl. The results were as follows: O,S-dicarbethoxythiamine [137-76-8] (29.64%), thiamine tetrahydrofurfuryl disulfide [804-30-8] (24.86%), O-benzoylthiamine monophosphate [22457-89-2] (21.66%), O-benzoylthiamine disulfide [2667-89-2] (21.49%), thiamine 8-(methyl-6-acetyldihydrothioctate) disulfide [137-86-0] (20.42%), N-[1-(2-oxo-1,3-oxathian-4-ylidene)ethyl]-N-[(4-amino-2-methyl-5-pyrimi dyl)methyl]formamide) [6092-18-8] (28.84%). .

Evaluation of thiamin derivatives

Evaluation of thiamin derivatives. Human bioavailability, uptake by human blood cells, and conversion to thiamin by rat liver homogenate. Itokawa, Yoshinori; Nishino, Kohsuke; Igarashi, Shogo (Fac. Med., Kyoto Univ., Kyoto 606-01, Japan). Bitamin, 66(1), 35-42 (Japanese) 1992. CODEN: BTMNA7. ISSN: 0006-386X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 18 To evaluate the merits of com. available leading thiamin derivs., thiamin tetrahydrofurfuryl disulfide (TTFD), O-benzoylthiamin disulfide (BTDS), and S-benzoylthiamin O-monophosphate (BTMP), were studied in the following 3 expts. The requirements of com. available thiamin derivs. are also discussed from the point of view of effectiveness and safety. Com. tablets contg. 100 mg of TTFD, or BTDS and a powder formulation contg. 100 mg of thiamin were administered to healthy subjects and their bioavailability was evaluated by detg. the blood concn. and urinary excretion of thiamin. It was found that the bioavailability of TTFD was better than that of BTCS or thiamin, according to the indexes of Cmax, Tmax, AUC, and the 48-h urinary excretion of thiamin. An in vitro test was carried out to compare the uptake of TTFD, BTDS, BTMP, and thiamin into human blood cells. Most of the TTFD was incorporated by blood cells and converted into thiamin, but BTDS and thiamin largely remained in the supernatant. Most of the BTMP was not converted into thiamin under these exptl. conditions. An in vitro test of the conversion of thiamin derivs. to thiamin by rat liver homogenate showed that TTFD was readily converted to thiamin by either fresh or boiled liver homogenate. BTDS was rapidly converted to O-benzoylthiamin (OBT), an intermediate metabolite, but conversion from O-benzoylthiamin to thiamin was very slow. BTMP was converted to thiamin fairly readily by fresh liver homogenate, but conversion was negligible when boiled liver homogenate was used.Except for chemicals metioned above, 2667-89-2 and 22457-89-2 are also used. .