Detail of "2679-14-3"

Reference

Effects of N-methylamino acids and convulsants on spontaneous action potentials in guinea pig cerebellar slices

Effects of N-methylamino acids and convulsants on spontaneous action potentials in guinea pig cerebellar slices. Okamoto, K.; Quastel, J. H. (Div. Neurol. Sci., Univ. British Columbia, Vancouver, B. C., Can.). Br. J. Pharmacol., 59(4), 551-60 (English) 1977. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 1 N-methyl-GABA [1119-48-8], N-methylglycine [107-97-1], N-methyltaurine [107-68-6], and N-methyl-.beta.-alanine [2679-14-3] diminished the frequency of spontaneous spike discharges in guinea pig cerebellar slices. The convulsants, picrotoxin [124-87-8] and strychnine [57-24-9] antagonized the inhibitory actions of all the amino acids except N-methylglycine, which was only antagonized by strychnine. N-methyl-DL-glutamate (I) [35989-16-3] caused a strong inhibition followed by a strong excitation of the neurons, and both convulsants completely suppressed the inhibitory effects but had no effect on the excitation. The no. of amino acid mols. combining with the receptor site to produce a response was 3, 2, 3, 3, and 1 for N-methyl-GABA, N-methylglycine, N-methyltaurine, N-methyl-.beta.-alanine, and I resp. The no. of convulsant mols. combining with the receptor site was 2 for picrotoxin with N-methyl-GABA, N-methyl-.beta.-alanine, and I and 1 for strychnine with all the amino acids.

Cleaning solution composition

Cleaning solution composition. (Lion Corp., Japan). Jpn. Kokai Tokkyo Koho JP 58162698 A2 27 Sep 1983 Showa, 6 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C11D001-83. 2679-14-3 and 57-50-1 are cas registry numbers. These chemicals are also mentioned in this article. ICI: C11D001-83, C11D001-10, C11D001-66. APPLICATION: JP 82-45967 23 Mar 1982. DOCUMENT TYPE: Patent CA Section: 46 (Surface Active Agents and Detergents) The cleaning compn. consists of (1) an alkali metal, NH4, or substituted-ammonium salt of an N-acylated [C10-14 (av.) acyl group] N-methyl-b-alanine, (2) an alk. earth metal salt of the above N-methyl-b-alanine, and (3) a nonionic surfactant. The relative limit of the 3 components in the compn. are 47.5-95, 2.5-50, and 2.5-50%, resp., and the pH of the compn. is 5-7.5. The compn. is smooth to the skin and yet has high cleaning power. Thus, a mixt. of C12-acylated N-methyl-b-alanine (I) Na salt 95, I Mg salt 2.5, and saccharose ester with palm oil fatty acid 2.5 parts showed high cleaning power at 0.1% concn. for glass plates greased with a mixt. of soybean oil and beef tallow. .