Reference

Hair tonics containing 4-androsten-3-one-17b-carboxylic acid alkyl esters

Hair tonics containing 4-androsten-3-one-17b-carboxylic acid alkyl esters. (Shiseido Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59184114 A2 19 Oct 1984 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K007-06. APPLICATION: JP 83-57399 1 Apr 1983. DOCUMENT TYPE: Patent CA Section: 62 (Essential Oils and Cosmetics) Hair tonics contain 4-androsten-3-one-17b-carboxylic acid alkyl esters (I) (R = C1-10 alkyl) as active ingredients. Thus, a hair tonic consists of 4-androsten-3-one-17b-carboxylic acid Me ester [2681-55-2] 8.0, 95% EtOH 77.0, ion exchanged water 13.98, hardened castor oil ethylene oxide adduct 1.0, hinokitiol 0.01 and viotin 0.01% and perfumes and colors.

Synthesis of 4-aza-3-oxo-androstane-17b-carboxylic acid, a key intermediate for the preparation of potent 5a-reductase inhibitors

Synthesis of 4-aza-3-oxo-androstane-17b-carboxylic acid, a key intermediate for the preparation of potent 5a-reductase inhibitors. Kan, Wai Ming; Yek, Yung Lee; Wang, Yao-Hsien; Chern, Ching-Yuh ( Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan). Chinese Pharmaceutical Journal (Taipei, Taiwan), 55(3), 213-219 (English) 2003 Pharmaceutical Society of Republic of China.There are some reagents with their cas registry numbers 2681-55-2 and 92472-33-8 are used in this study. CODEN: CPHJEP. ISSN: 1016-1015. DOCUMENT TYPE: Journal CA Section: 32 (Steroids) A key intermediate, 4-aza-3-oxo-androstane-17b-carboxylic acid (I), for the prepn. of some potent 5a-reductase inhibitors was synthesized in 5 steps from the known Me 3-oxo-4-androstene-17b carboxylate (II). The construction of 4-aza-3-oxo-ring A of the steroid was achieved conveniently by a novel one-step simultaneous lactam formation and N-debenzylation of Me 3-(2,4-dimethoxylbenzylamine)-5-oxo-A-nor-3,4-seco-androstane-17b- carboxylate with benzylated aza-androstane-17b-carboxylate intermediate equiv. of p-TsOH. .