Detail of "2683-90-1"

CAS Number:
2683-90-1
Name:
7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,3,6-dihydro-
Molecular Structure:
Formula:
C₄H₃N₅O
Molecular Weight:
137.1
Synonyms:
7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,1,4-dihydro- (9CI);7H-v-Triazolo[4,5-d]pyrimidin-7-one, 1,6-dihydro-(6CI,7CI,8CI);1H-1,2,3-Triazolo[4,5-d]pyrimidin-7-ol;1H-v-Triazolo[4,5-d]pyrimidin-7-ol;7-Hydroxy-1,2,3,4,6-pentaazaindene;7-Hydroxy-v-triazolo[d]pyrimidine;8-Azahypoxanthine;NSC 22709;
EINECS:
220-244-3
Density:
2.26 g/cm³
Boiling Point:
228.1 °C at 760 mmHg
Flash Point:
91.7 °C
Appearance:
Light yellow to light beige fine crystalline
Risk Codes:
36/37/38
Safety:
24/25 Details

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8-AZAHYPOXANTHINE

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8-Azahypoxanthine

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Radioprotective effect and toxicity of sulfur- and nitrogen-containing heterocycles: Radioprotective effect and toxicity of sulfur- and nitrogen-containing heterocycles. Krutovskikh, G. N.Several substances are used for example 62700-63-4 and 2683-90-1 which are their cas registry numbers.; Rusanov, A. M.; Gornaeva, G. F.; Vartanyan, L. P.; Kolesova, M. R.; Muravich-Aleksandr, Kh. L.; Smirnova, N. V.; Cherkazova, S. S. (Tsentr. Nauchno-Issled. Rentgeno-Radiol. Inst., Leningrad, USSR). Khim.-Farm. Zh., 11(2), 82-9 (Russian) 1977. CODEN: KHFZAN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 Among the 25 heterocyclic compds. synthesized and tested, only a few 8-azaxanthine derivs. had significant radioprotective effects. The most active compd. was 1,3,9-trimethyl-8-azaxanthine (I) [2278-16-2], which at 350 mg/kg i.p. brought about 25% survival of mice subjected to x-irradn. lethal to controls. The activity of the compds. was detd. primarily by the oxo, Me, and MeO groups on the rings. .

Radiomodifying effect of 8-azahypoxanthine: Radiomodifying effect of 8-azahypoxanthine. Volchkov, V.Several substances are used for example 2683-90-1 which is its cas registry number. A.; Mikhailova, N. Ya. (Cent. Sci. Res. Inst. Roentgenol. Radiol., Leningrad, USSR). Radiobiologiya, 24(1), 90-2 (Russian) 1984. CODEN: RADOA8. ISSN: 0033-8192. DOCUMENT TYPE: Journal CA Section: 8 (Radiation Biochemistry) 8-Azahypoxanthine (100 mg/kg) administered i.p. to mice immediately after exposure to x-irradn. (7 Gy) had a radiosensitizing effect on hematopoietic stem cells. In mice with RL-67 tumors or leukosis La, 8-azahypoxanthine also increased the radiosensitivity of the neoplastic cells. .