Reference

Cholinesterase enzyme inhibition by some antiarrhythmic drugs in vitro

Cholinesterase enzyme inhibition by some antiarrhythmic drugs in vitro. Alkondon, M.; Roy, A.; Sen, P. (Dep. Pharmacol., Univ. Coll. Med. Sci., New Delhi, India). Indian J. Pharmacol., 15(2), 85-9 (English) 1983. CODEN: INJPD2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Antiarrhythmic drugs such as b-blockers, antimalarials, and local anesthetics dose-dependently inhibited both pseudo- and eu- cholinesterase (ChE) [9001-08-5] activity. Plasma and red blood cells served as the source of pseudo- and eu-ChE, resp. A 50% inhibition of pseudo-ChE enzyme was achieved at concns. of 10-6-10-5M by some drugs, but a similar inhibition of eu-ChE could not be achieved with any of the drugs at concns. <10-3M except physostigmine salicylate [57-64-7]. The order of potency for inhibition of pseudo-ChE activity was: physostigmine > quinidine [56-54-2] > UM-272 [38726-81-7] > (±)-propranolol [13013-17-7] > chloroquine [54-05-7] > quinine [130-95-0] > procainamide [51-06-9] > lignocaine [137-58-6] > timolol maleate [26921-17-5] > sotalol [3930-20-9]. A good correlation was demonstrated between the in vitro inhibition of pseudo-ChE activity by these compds. and their antagonism of ouabain-induced arrhythmia in dogs.

Are b-adrenergic mechanisms involved in ocular hypotensive actions of adrenergic drugs?

Are b-adrenergic mechanisms involved in ocular hypotensive actions of adrenergic drugs?. Chiou, George C. Y.; Watanabe, Kazuhito; McLaughlin, Marsha A.; Liu, Hsin K. (Coll. Med., Texas A and M Univ., College Station, TX 77843, USA). Ophthalmic Res., 17(1), 49-53 (English) 1985. CODEN: OPRSAQ. ISSN: 0030-3747. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 In cats, tazolol (I) [39832-48-9] (b1-agonist) reduced the formation of aq. humor more than the outflow, whereas metoprolol [37350-58-6] (b1-antagonist) reduced the outflow of aq. humor more than its formation. Both salbutamol [18559-94-9] (b2-agonist) and butoxamine [1937-89-9] (b2-antagonist) inhibited aq. humor formation and aq. humor outflow to an equal extent. Receptor binding expts. on the iris-ciliary body prepns. from rabbits clearly showed that there are 40-fold and 281-fold differences in binding affinity of d- [26839-77-0] and l-timolol maleate [26921-17-5] and d- [5051-22-9] and l-propranolol [4199-09-1], resp. Thus, adrenergic receptor mechanisms exist in the eye tissues, but do not control intraocular pressure significantly.