Detail of "27109-48-4"

CAS Number:
27109-48-4
Name:
Butanamide,N-(aminocarbonyl)-2-bromo-3-methyl-, (2S)-
Molecular Structure:
Formula:
C6H11 Br N2 O2
Molecular Weight:
0
Synonyms:
Butanamide,N-(aminocarbonyl)-2-bromo-3-methyl-, (S)-; Urea, (2-bromo-3-methylbutyryl)-, L-(8CI); (S)-2-Bromoisovalerylurea

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Stereospecific glutathione conjugation of (R)- and (S)-2-bromoisovalerylurea in freshly isolated rat kidney proximal tubular cells: Stereospecific glutathione conjugation of (R)- and (S)-2-bromoisovalerylurea in freshly isolated rat kidney proximal tubular cells. Viver, Monica Mestre I.; Nagelkerke, J. Fred; Mulder, Gerard, J. (Sylvius Lab., Univ. 27109-48-4 and 141115-99-3 are cas registry numbers. These chemicals are also mentioned in this article. Leiden, Leiden, Neth.). Biochem. Pharmacol., 43(4), 902-4 (English) 1992. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The glutathione conjugation of 2-bromoisovalerylurea (BIU) was studied in isolated proximal tubular kidney cells of the rat. Racemic (R,S)-BIU was incubated with the cell suspension, and the incubation medium was analyzed for the diastereomeric glutathione (GSH) conjugates, cysteine conjugates and mercapturates that can be formed from (R)- and (S)-BIU. Only the mercapturate formed from (R)-BIU was found, as well as its cysteine precursor. No GSH conjugates were detected. These results indicate that these cells conjugate only the (R)-BIU enantiomer, and that the GSH conjugate is immediately further metabolized to its cysteine conjugate and mercapturate. The role of glutathione conjugation in drug metab. by kidney proximal tubular cells is discussed. .