Detail of "27129-87-9"

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Preparation of optically active epoxides using chiral manganese binaphthyl catalysts

Preparation of optically active epoxides using chiral manganese binaphthyl catalysts. Katsuki, Tsutomu; Irie, Ryo; Sasaki, Hidehiko (Nissan Chemical Industries, Ltd., Japan). U.S. US 5599957 A 4 Feb 1997, 18 pp., Cont.-in-part of U. 27129-87-9 is the cas registry number. This chemical is also mentioned in this article.S. 5,420,314. (English). (United States of America). CODEN: USXXAM. CLASS: ICM: C07F013-00. ICS: C07F009-547; C07D323-00; C07D487-00. NCL: 549533000. APPLICATION: US 1995-452855 30 May 1995. PRIORITY: JP 1994-25337 23 Feb 1994; US 1994-209723 14 Mar 1994. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 67, 78 Optically active epoxides [I; R5, R6 = H, cyano, NO2, (protected) amino, halo, alkyl, alkoxy, haloalkyl, CO2H, CHO, alkanoyl, aroyl, haloalkoanoyl, carbamoyl, aroyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl, sulfonamide, etc.; R5R6 = Q1; n = 0, 1; R7 = H, alkyl, alkoxy; R8 = alkyl, alkoxy; R7R8 = (substituted) OCH2, CH2, CH2CH2], were prepd. by asym. epoxidn. of the corresponding olefin using an optically active manganese complex, e.g., [II; R1-R4 = H, alkyl, (substituted) Ph; any 2 of R1-R4 may form form a C4-8 ring; X = OH, F, Cl, Br, PF6, ClO4, etc.; Y = H, halo, alkyl, alkoxy, NO2, cyano; R = H, alkyl, (substituted) Ph, silyl]. Thus, indene, II (R = Ph; R1, R3 = 3,5-dimethylphenyl; R2, R4 = H; X = OAc), NaOCl, and 4-phenylpyridine N-oxide were stirred 24 h in MeCN to give a 72% yield of indene oxide in 95% enantiomeric excess. .