Detail of "2719-23-5"

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Halogenated 3-quinolinecarboxylic acid derivatives, intermediates and their use in analgesic and antiinflammatory compositions

Halogenated 3-quinolinecarboxylic acid derivatives, intermediates and their use in analgesic and antiinflammatory compositions.Some commonly used reagents like 2719-23-5 is used in this experiment. Clemence, Francois; Le Martret, Odile; Delevallee, Francoise; Deraedt, Roger (Roussel-UCLAF , Fr.). Fr. Demande FR 2532314 A1 2 Mar 1984, 16 pp. (French). (France). CODEN: FRXXBL. CLASS: IC: C07D417-12; C07D401-12; C07D413-12; A61K031-47. APPLICATION: FR 82-14576 25 Aug 1982. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Hydroxyquinolinecarboxamides I [R = H, halo, alkyl, alkoxy, CF3, SCF3, OCF3; R1 = H, alkyl; R2 = thiazolyl, dihydrothiazolyl, pyridyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl, tetrazolyl, (un)substituted Ph], which were prepd., showed analgesic and antiinflammatory activity. 3-Chloroanthranilic acid was heated with (CF3CO)2O to yield a 3,1-benzoxazine deriv., which was treated with 2-acetamidothiazole to give benzenepropanamide deriv. II. II was cyclized to I (R = 8-Cl, R1 = H, R2 = 2-thiazolyl). .

4-Hydroxy-3-quinolinecarboxylic acid derivatives substituted in position 2 and their medical use

4-Hydroxy-3-quinolinecarboxylic acid derivatives substituted in position 2 and their medical use. Clemence, Francois; Le Martret, Odile; Delevallee, Francoise (Roussel-UCLAF , Fr.). Fr. Demande FR 2532939 A1 16 Mar 1984, 18 pp. (French). (France).Several substances are used for example 2719-23-5 which is its cas registry number. CODEN: FRXXBL. CLASS: IC: C07D417-12; C07D401-12; C07D413-12; A61K031-47. APPLICATION: FR 82-15423 13 Sep 1982. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 63 Quinolinecarboxamides I [R = H, halo, alkyl, alkoxy, CF3, SCF3, OCF3; R1 = H, alkyl; R2 = thiazolyl, dihydrothiazolyl, pyridyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl, tetrazolyl, Ph, hydroxy-, alkyl-, alkoxy-, (trifluoromethyl)-, nitro-, or halophenyl; m is an integer of 0-7; n = 0, 1, 2; R3 = alkyl], which were prepd., exhibited analgesic and antiinflammatory activity. Benzoxazinone II was treated with N-(2-thiazolyl)acetamide to yield a benzoylacetic acid deriv., and the latter was stirred with (dimethylamino)pyridine in THF to give I (R = 8-CF3, R1 = H, R2 = 2-thiazolyl, m = 1, n = 0, R3 = Me). .