Detail of "27262-48-2"

CAS Number:
27262-48-2
Name:
Levobupivacaine hydrochloride
Molecular Structure:
Formula:
C₁₈H₂₉ClN₂O
Molecular Weight:
324.89
Synonyms:
2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride, (2S)- (9CI);2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride,(S)-;2',6'-Pipecoloxylidide, 1-butyl-, monohydrochloride, (-)- (8CI);(-)-Bupivacaine monohydrochloride;(S)-(-)-Bupivacaine monohydrochloride;Chirocaine;Popscaine;Levobupivacaine HCL;
Melting Point:
254 °C (dec.)(lit.)
Boiling Point:
423.4 °C at 760 mmHg
Flash Point:
209.9 °C
Appearance:
white crystalline powder
Hazard Symbols:
T+, Xn
Risk Codes:
26/27/28-20/21/22-28
Safety:
22-36/37/39-45-36/37-53 Details
Transport Information:
UN 2811 6.1/PG 2

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Reference

Levobupivacaine for pediatric spinal anesthesia: Some chemicals with cas registry numbers like 27262-48-2 are also used. Levobupivacaine for pediatric spinal anesthesia. Kokki, Hannu; Ylonen, Paula; Heikkinen, Marja; Reinikainen, Matti ( Departments of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland). Anesthesia & Analgesia (Hagerstown, MD, United States), Volume Date 2004, 98(1), 64-67 (English) 2003 Lippincott Williams & Wilkins. CODEN: AACRAT. ISSN: 0003-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In this clin. trial we evaluated the clin. effects of levobupivacaine in spinal anesthesia in children. An open, noncomparative study was performed on 40 children, aged 1 - 14 yr, undergoing elective lower abdominal or lower, limb surgery. A plain soln. of S(-) bupivacaine 5 mg/mL at a mean dose of 0.3 mg/kg body wt. (range, 0.2 - 0.5 mg/kg body wt.) was administered via the L3-4 or L4-5 interspace with the patient in the lateral decubitus position. After injection, the patients were placed supine. The spread and duration of sensory analgesia and the degree of motor block were recorded. Satisfactory surgical anesthesia was achieved in 39 of the 40 children. One child received supplemental anesthesia. The mean highest level of sensory block was T4 (range, T2 to L1), and the mean time to the regression of sensory block to T10 was 90 min (range, 43 - 185 min). A complete motor block was achieved in 36 children. These results are similar to those obtained with racemic bupivacaine in subarachnoid anesthesia in children. .

A comparison of duration of analgesia of intrathecal 2: A comparison of duration of analgesia of intrathecal 2.5 mg of bupivacaine, ropivacaine, and levobupivacaine in combined spinal epidural analgesia for patients in labor. Lim, Yvonne; Ocampo, Cecilia E.; Sia, Alex T. (Department of Anesthesia, KK Women's and Children's Hospital, Singapore). Anesthesia & Analgesia (Hagerstown, MD, United States), Volume Date 2004, 98(1), 235-239 (English) 2003 Lippincott Williams & Wilkins. CODEN: AACRAT. ISSN: 0003-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) We assessed the duration of labor analgesia rendered by intrathecal (IT) local anesthetics as the sole drugs. In this randomized, controlled, and double-blinded study, labor analgesia was induced using combined spinal-epidural technique in 60 ASA phys. status I nulliparous parturients with IT bupivacaine 2.5 mg (group B), ropivacaine 2.5 mg (group R), or levobupivacaine 2.5 mg (group L). Pain scores (0 - 100 visual analog scale) and blood pressure were recorded pre-block and for the first 30 min post-block. The degree of motor block and the highest sensory block were also monitored. The duration of analgesia (our primary outcome) was the longest in group B but was similar between groups R and L (mean ± SE, 76.3 ± 5.9 min vs. 52.6 ± 4.0 min and 51.5 ± 3.4 min, resp., P < 0.05). Group B had the most frequent incidence of lower limb motor block but there was no difference between groups R and L (5 of 20 parturients vs. 2 of 20 and 0 of 20, resp.In this experiment, several chemicals are used like 38396-39-3 and 27262-48-2 , P < 0.05). The profile of the other side effects was indistinguishable between the groups. With the current regimen, IT bupivacaine produced the longest duration of labor analgesia. .

Detail of "27262-48-2"

Levobupivacaine hydrochloride

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CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

CAS No.27262-48-2 Levobupivacaine hydrochloride

Reference