Detail of "27299-12-3"

Reference

Preparation of purinyl- and pyrimidinyltetrahydrofurans as antiviral agents

Preparation of purinyl- and pyrimidinyltetrahydrofurans as antiviral agents. Zahler, Robert; Goodfellow, Val S.; Ahmad, Saleem (Squibb, E. R., and Sons, Inc., USA). Eur. Pat. Appl. EP 464769 A2 8 Jan 1992, 27 pp.Several reagents with their cas registry numbers 50-70-4 and 27299-12-3 are used here. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D473-00. ICS: C07D239-54; C07D239-46; A61K031-52; A61K031-505. APPLICATION: EP 91-110945 2 Jul 1991. PRIORITY: US 90-546957 2 Jul 1990. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Section cross-reference(s): 1 Title compds. [I; R1 = Q1 in which R = H, R7R8 = O, R9 = NH2; R1 = Q1 in which R = H, R7R8 = O, R9 = H; R1 = Q1 in which RR7 = bond, R8 = NH2, R9 = H; R1 = Q1 in which RR7 = bond, R8 = NH2, R9 = NH2; R1 = Q1 in which RR7 = bond, R8 = H, R9 = NH2; R1 = Q2 in which R = H, R7R8 = O; R1 = Q2 in which RR7 = bond, R8 = NH2; R2 = H, halo, Me, CF3, (Z)-CH:CHR3, etc.; R3 = H, halo, Me, CF3; R4, R5 = H, P(O)(OH)2, COR6; R6 = H, (substituted) alkyl] were prepd. Thus, D-sorbitol was converted in 9 steps to [2R-(2a,3b,4b)]-3,4-epoxytetrahydro-2-[[(4-methoxyphenyl)diphenylmet hoxy]methyl]furan which was condensed with 6-(phenylmethoxy)-9H-purin-2-amine to give, after deprotection, I (R1 = Q1, R = R4, = R5 = H, R7R8 = O, R9 = NH2). The latter had IC50 of 2-5 and 2 mg/mL against herpes simplex virus type 1 (strain Schooler) and type 2 (strain 186) resp. .

Enzymatic synthesis of sorbitan methacrylate: comparison of methacrylic acid and vinyl methacrylate

All Rights Reserved. Enzymatic synthesis of sorbitan methacrylate: comparison of methacrylic acid and vinyl methacrylate. Jeong, Gwi-Taek; Byun, Ki-Young; Lee, Woo-Tai; Ryu, Hwa-Won; Sunwoo, Changshin; Kim, Hae-Sung; Park, Don-Hee (Engineering Research Institute, Chonnam National University, Gwangju 500-757, S. Korea). Biochemical Engineering Journal, 29(1-2), 69-74 (English) 2006 Elsevier B.V. CODEN: BEJOFV.Several reagents with their cas registry numbers 9001-62-1 and 27299-12-3 are used here. ISSN: 1369-703X. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) "Biomaterials" is a generic term which refers to a variety of medical material which is designed to be in direct contact with living tissue. Clearly, biomaterials must be carefully and microscopically fabricated for optimal acceptance within the living organism, in both functional and structural senses. In this study, the enzymic synthesis of sorbitan methacrylate from 1,4-sorbitan via the manipulation of an immobilized biocatalyst (Novozym 435) and acyl donors (methacrylic acid and vinyl methacrylate) was evaluated. The conversion yield of sorbitan methacrylate was found to be 80.4% under the following exptl. conditions: 1:3 molar ratio of 1,4-sorbitan and vinyl methacrylate, reaction temp. of 50°, initial sorbitan concn. of 50 g/L, and 3% (w/v) Novozym 435. .