CAS No.2748-02-9,L-Leucine,1,1-dimethylethyl ester, hydrochloride (1:1) Suppliers

Detail of "2748-02-9"

CAS Number:

2748-02-9

Name:

L-Leucine,1,1-dimethylethyl ester, hydrochloride (1:1)

Superlist Name:

L-Leucine tert-butyl ester hydrochloride

Molecular Structure:

Formula:

C₁₀H₂₂ClNO₂

Molecular Weight:

223.74

Synonyms:

L-Leucine,1,1-dimethylethyl ester, hydrochloride (9CI);Leucine, tert-butyl ester,hydrochloride (6CI,7CI);Leucine, tert-butyl ester, hydrochloride, L- (8CI);L-Leucine tert-butyl ester hydrochloride;L-Leucine tert-butyl esterhydrochloride;tert-Butyl (S)-2-amino-4-methylpentanoate hydrochloride;tert-Butyl L-leucinate hydrochloride;H-Leu-OtBu·HCl;

Boiling Point:

222.4 °C at 760 mmHg

Flash Point:

90.3 °C

Appearance:

Crystalline

Reference

Preparation of tripeptides contg: Preparation of tripeptides contg. histidyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors. Namihana, Yoshimitsu; Okada, Masahiro; Mimura, Hirohide; Hayashi, Takami; Muratani, Emiko; Takeyasu, Takumi; Fujii, Katsuhiko (Teijin Ltd, Japan). Jpn. Kokai Tokkyo Koho JP 09025293 A2 28 Jan 1997 Heisei, 28 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07K005-083. 2748-02-9 and 2488-22-4 are cas registry numbers. These chemicals are also mentioned in this article. ICS: A61K038-55; C07K005-087; C07K005-09; C07K005-093; C07K005-097. APPLICATION: JP 1996-22420 8 Feb 1996. PRIORITY: JP 1995-25204 14 Feb 1995; JP 1995-110529 9 May 1995. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 63 Tripeptides contg. histidine hydroxamic acid represented by formula R7R6NCzHR5CONHR4CyHR3CONR2CxHR1CONHOH (I; R1 = imidazolylmethyl; R2, R4, R6 = H, C1-5 alkyl; R3 = H, C1-5 alkyl, C2-5 alkenyl, C7-20 aralkyl, C4-10 heteroaralkyl, carboxy-C1-5 alkyl, C7-20 aralkoxycarbonyl-C1-5 alkyl, carbamoyl-C1-5 alkyl, etc.; or R3 and R4 are linked together for NR4CyHR3 to form pyrrolidinyl group; R5 = H, C1-5 alkyl, C7-20 aralkyl, C4-10 heteroaralkyl, carbamoyl-C1-5 alkyl; or R5 and R6 are linked together for R6NCzHR5 to form pyrrolidinyl or 5-oxopyrrolidinyl group; R7 = H, C1-5 acyl, Bz, naphthoyl, C7-20 aralkylcarbonyl, C1-5 alkoxycarbonyl, C7-20 aralkoxycarbonyl, C1-5 alkylsulfonyl, PhSO2, naphthylsulfonyl; when Cz, Cy, and Cx are asym. C atoms, the abs. configuration is S or R) are prepd. An inhibitor of matrix metalloproteinase, in particular stromelysin (matrix metalloproteinase-3 or MMP-3) contg. above tripeptide hydroxamic acid deriv. I is claimed. Thus, Z-Ala-Leu-His-OH was prepd. by the solid phase method which involved sequential coupling of Fmoc-Leu-OH and Z-Ala-OH to Fmoc-His-resin and condensed with hydroxylamine hydrochloride using HOBt,PyBOP, and N-methylmorpholine in DMF to give Z-Ala-Leu-His-NHOH (II). II and Z-Pro(5-oxo)-D-Leu-D-His-NHOH showed IC50 of 2.5 and 2.2 mM, resp., against MMP-3 (stromelysin) and 6.1 and 0.18 mM, resp., against MMP-9 (gelatinase). An ampule contg. II was formulated. .

Detail of "2748-02-9"

L-Leucine,1,1-dimethylethyl ester, hydrochloride (1:1)

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CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

CAS No.2748-02-9 L-Leucine tert-butyl ester hydrochloride

Reference