Detail of "2752-65-0"

Reference

Effect of gambogic acid on cell cycle of HeLa cells

Effect of gambogic acid on cell cycle of HeLa cells. Qiu, Xianghuan; Song, Pinggen; Xue, Shaobai (Dep. Biol., Beijing Norm. Univ., Beijing, Peop. Rep. China).In this article, certain chemicals are used. One of their cas registry numbers is 2752-65-0 Zhongyao Tongbao, 11(10), 627-9 (Chinese) 1986. CODEN: CYTPDT. ISSN: 0254-0029. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In HeLa cell cultures, gambogic acid (I) [2752-65-0] decreased the no. of the cells in G1, S, and M phases but increased it in the G2 phase, as detd. by flow cytometry and premature chromatin coagulation method. Apparently, I inhibits the growth of HeLa cells by interfering with the cell cycle at the G2 phase. .

Determination of gambogic acid in human plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry

All Rights Reserved. Determination of gambogic acid in human plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Ding, Li; Huang, Di; Wang, Jinwan; Li, Shuting (Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, Peop. Rep. China). Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 846(1-2), 112-118 (English) 2007 Elsevier B.V. CODEN: JCBAAI. ISSN: 1570-0232. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A high-performance liq. 2752-65-0 is the cas registry number. This chemical is also mentioned in this article. chromatog.-atm. pressure chem. ionization-mass spectrometry (HPLC-APCI-MS) method was established for the detn. of gambogic acid (GA) in human plasma using ursolic acid as the internal std. (I.S.). Plasma samples were extd. with Et acetate and sepd. on a Hanbon Lichrospher 5-C18 column with a mobile phase of acetonitrile-tetrahydrofuran-water (:7, vol./vol.). Gambogic acid was detd. by using atm. pressure chem. ionization (APCI) in a single quadrupole mass spectrometer. HPLC-APCI-MS was performed in the selected ion monitoring (SIM) mode using target ions at [M-H]- m/z 627.4 for gambogic acid and [M-H]- m/z 455.4 for the I.S. Calibration curve was linear over the range of 3.108-4144 mg/L. The lower limit of quantification was 3.108 mg/L. The intra- and inter-run precisions were less than 12.3 and 14.1%, resp. The method has been successfully applied to study the pharmacokinetics of gambogic acid in patients with malignant tumor. .