Detail of "2763-96-4"

Reference

Properties of g-aminobutyric acid receptor/ionophore proteins from crayfish muscle

Properties of g-aminobutyric acid receptor/ionophore proteins from crayfish muscle. Olsen, Richard W.; Meiners, Brad; Kehoe, Pat; Ticku, Maharaj K. (Dep. Biochem., Univ. California, Riverside, Calif., USA). Biochem. Soc. Trans., 5(4), 863-6 (English) 1977. CODEN: BCSTB5. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 12 Labeled Cl- uptake by abdominal muscle of the crayfish, Procambarus clarkii, was increased by GABA [56-12-2] (200mM); the GABA effect was dose-dependent with half-max. response at 40mM. Picrotoxinin (II) [17617-45-7] inhibition of GABA-stimulated Cl- uptake was also dose-dependent with half-max. inhibition at 3-4mM; the GABA effect on Cl- uptake was mimicked by muscimol [2763-96-4] (40mM). GABA biding to particulate fractions of crayfish muscle was inhibited 50-70% by 3mM muscimol, half-max. inhibition occurring at concns. of ~1mM muscimol. Binding of labeled a-dihydro-II to crayfish muscle microsomal fractions was ~2 pmol/mg of protein, approx. equal to the amt. of muscimol-sensitive sites. Sucrose-gradient anal. of crayfish muscle microsomal fractions showed that GABA uptake was assocd. with fractions appearing at 0.75-1.0M sucrose whereas muscimol-sensitive GABA binding and a-dihydro-II binding were assocd. with membrane fragments appearing in fractions at 0.9-1.1M sucrose. Thus muscimol-sensitive sites do not appear to be related to the GABA uptake process but may be receptor sites; binding of GABA and II appear to be related to GABA receptor/ionophore macromols.

Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists

Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists. Olpe, H. R.; Schellenberg, H.; Koella, W. P. (Res. Lab., Ciba-Geigy Ltd., Basel, Switz.). Eur. J. Pharmacol., 45(3), 291-4 (English) 1977. CODEN: EJPHAZ. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 1 GABA [56-12-2] and GABA-related drugs such as muscimol, [2763-96-4] g-hydroxybutyric acid [591-81-1], and baclofen [1134-47-0] injected unilaterally into the substantia nigra of rats elicited contraversive turning. Unilateral injections of picrotoxin and bicuculline produced either ipsi- or contraversive turning depending on the vol. of vehicle. I.p. applied haloperidol did not abolish the muscimol-induced turning. This latter observation and the direction of rotational behavior suggests that the turning behavior elicited by GABA-related drugs is not mediated by the nigrostriatal dopaminergic tract.