Detail of "2777-65-3"

Reference

Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids

Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids. Ortiz de Montellano, Paul R.; Reich, Norbert O. (Sch. Pharm., Univ. California, San Francisco, CA 94143, USA). J. Biol. Chem., 259(7), 4136-41 (English) 1984. CODEN: JBCHA3. ISSN: 0021-9258. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) The terminal acetylenic analog of lauric acid, 11-dodecynoic acid (11-DDYA), specifically inactivated hepatic cytochrome P 450 enzymes that catalyze w- and w-1-hydroxylation of lauric acid. The inactivation, as required for a suicidal process, was NADPH- and time-dependent and followed pseudo-1st order kinetics. In contrast, 11-DDYA caused no measurable change in the spectroscopically measured concn. of cytochrome P 450 or in the N-demethylation of benzphetamine or N-Me p-chloroaniline. 10-Undecynoic acid was as effective a suicide substrate for fatty acid hydroxylases as 11-DDYA, but 11-dodecenoic acid was much less effective. 11-DDYA was able to completely inhibit w-hydroxylation despite the fact that both activities were completely inactivated by 1-aminobenzotriazole.There are some commonly used reagents with their cas registry numbers 16900-60-0 and 90265-01-3 in this article. At least 3 hepatic cytochrome P 450 fatty acid hydroxylases, 1 w-hydroxylase and 2 w-1-hydroxylases, were required by these results. The construction of suicide substrates that specifically inactivate cytochrome P 450 fatty acid hydroxylases thus provides a new exptl. probe for the physiol. role of this process. .

Phosphatidylcholine-Derived Bolaamphiphiles via Click Chemistry

All Rights Reserved.Some chemicals with cas registry numbers like 2777-65-3 are also used. Phosphatidylcholine-Derived Bolaamphiphiles via Click Chemistry. O'Neil, Edward J.; DiVittorio, Kristy M.; Smith, Bradley D. (Department of Chemistry Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA). Organic Letters, 9(2), 199-202 (English) 2007 American Chemical Society. CODEN: ORLEF7. ISSN: 1523-7060. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Section cross-reference(s): 22 The copper-catalyzed azide alkyne cycloaddn. is employed to modify phosphatidylcholine precursors with sn-2 acyl chains contg. terminal alkyne or azide groups. Although the reactions are conducted as biphasic dispersions, the yields are essentially quant. Bolaamphiphiles are formed by simply clicking together two phosphatidylcholine alkyne precursors to a central bis-azide scaffold. The chem. introduces polar 1,4-triazole units into the lipophilic region of the bilayer membrane, and the bolaamphiphiles do not form stable vesicles. .