Detail of > 28002-18-8
- CAS Number:
- 28002-18-8
- Name:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfoacetyl)amino]-, sodium salt (1:2),(2S,5R,6R)-
- Superlist Name:
- Sulbenicillin sodium
- Formula:
- C16H16N2Na2O7S2
- Molecular Structure:
![Molecular Structure of 28002-18-8 (4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfoacetyl)amino]-, sodium salt (1:2),(2S,5R,6R)-)](http://www.lookchem.com/300w/2010/078/28002-18-8.jpg)
- Synonyms:
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt, (2S,5R,6R)-(9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt, [2S-(2a,5a,6b)]-;Disodium sulbenicillin;Disodium sulfobenzylpenicillin;Kedacillin;Lilacillin;Sodium sulbenicillin;Sulbenicillin disodium;Sulbenicillin sodium;Sulfocillin;a-Sulfobenzylpenicillindisodium salt;a-Sulfobenzylpenicillinsodium salt;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido)-, disodium salt (8CI);a-Sulfocillin;
- Molecular Weight:
- 458.41
- EINECS:
- 248-769-3
Related products
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- 6489-61-84-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-[[(2R)-2-(methyleneamino)-2-phenylacetyl]amino]-7-oxo-,sodium salt (1:1), (2S,5R,6R)-
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Reference
- The in vitro activity of 15 penicillins and mecillinam against Neisseria gonorrhoeae
- The in vitro activity of 15 penicillins and mecillinam against Neisseria gonorrhoeae. Watts, Barry A.; Phillips, Ian; Stoate, Martin W. (Dep. Microbiol., St. Thomas's Hosp. Med. Sch., London, Engl.). J. Antimicrob. Chemother., 3(4), 331-7 (English) 1977. CODEN: JACHDX. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Min. inhibitory concns. (MIC's) of 15 penicillins and mecillinam were detd. on solid media for 92 strains of N. gonorrhoeae. Regression lines for MIC's of each antibiotic against those of benzylpenicillin Na [69-57-8] were calcd. The order of activity against benzylpenicillin-insensitive strains was ampicillin [69-53-4], amoxycillin [26787-78-0], azidocillin [17243-38-8] ticarcillin [34787-01-4] carbenicillin Na [4800-94-6], sulfocillin [28002-18-8], phenoxymethylpenicillin [87-08-1], methicillin [61-32-5], phenethicillin K [132-93-4], mecillinam [32887-01-7], propicillin K [1245-44-9], flucloxacillin [5250-39-5], nafcillin Na [985-16-0], cloxacillin Na [642-78-4] and dicloxacillin [3116-76-5]. The regressions for flucloxacillin, cloxacillin, and dicloxacillin were indistinguishable as were those of azidocillin, ticarcillin, and carbenicillin. Only ampicillin and amoxycillin showed greater activity than benzylpenicillin against relatively resistant strains.
- Determination of the stability of a-sulfocillin in 2% lidocaine and 10% dextrose solutions by high-pressure liquid chromatography
- Determination of the stability of a-sulfocillin in 2% lidocaine and 10% dextrose solutions by high-pressure liquid chromatography. Chen, Guoman (Hunan Inst. Drug Control, Changsha, Peop. Rep. China). Yaowu Fenxi Zazhi, 6(5), 278-9 (Chinese) 1986. CODEN: YFZADL. ISSN: 0254-1793. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64 a-Sulfocillin (I) [28002-18-8] was more stable in a 10% glucose [50-99-7] soln. than in 2% lidocaine [137-58-6] or in water. After storage at 26° for 96 h, the percentages of I remaining in 10% glucose, 2% lidocaine, and water were 83.38, 34.28, and 31.24%, resp. Reverse-phage liq. chromatog. with a C18 m-Bondapack column was used for detn. of the drug. The elution solvent contained 0.01M NH4OAc and MeOH at the ratio of .
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