Reference

Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate

Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. Katz, Gary V.; Krasavage, Walter J.; Terhaar, C. J. (Health Environ. Lab., Eastman Kodak Co., Rochester, NY 14650, USA). EHP, Environ. Health Perspect., 57, 165-75 (English) 1984. CODEN: EVHPAZ. ISSN: 0091-6765. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The acute toxicity of ethylene glycol monopropyl ether (EGPE) [2807-30-9] and ethylene glycol monopropyl ether acetate (EGPEA) [20706-25-6] were detd. in a series of standardized tests. The oral LD50 in rats was 3089 and 9456 mg/kg for EGPE and EGPEA, resp. Skin irritation was slight following an occluded single dose application of either compd. to the guinea pig abdomen. The dermal LD50 for guinea pigs was 1-5 and >20 mL/kg for EGPE and EGPEA, resp. EGPE produced a weak pos. sensitization response in 1 of 5 guinea pigs. No pos. response was elicited when 10 guinea pigs were similarly challenged with EGPEA, EGPE produced transient moderate to severe eye irritation in rabbits whereas EGPEA produced slight eye irritation. Subchronic toxicity was detd. in a series of oral and inhalation studies. Groups of 10 male rats were dosed with 15, 7.5, 3.75, or 1.88 mmole/kg EGPE and 30, 15, or 7.5 mmole/kg EGPEA by gavage 5 days/wk for 6 wk. Hemoglobinuria was seen at least once at all dose levels of both compds. EGPE had little effect on feed consumption or body wt. gain, while body wt. gain was reduced in the 2 high dose groups exposed to EGPEA and feed consumption was reduced at all dose levels. Hematol. changes were seen at all dose levels of both compds. Abs. and/or relative spleen wts. were increased at all but the lowest EGPE dose level and at all EGPEA dose levels. Gross and histopathol. examns. revealed significant effects on the spleen of animals exposed to EGPE and on the spleen, liver, kidney, and testes of animals exposed to EGPEA.

Interruption of cell-cell communication in Chinese hamster V-79 cells by various alkyl glycol ethers: implications for teratogenicity

Interruption of cell-cell communication in Chinese hamster V-79 cells by various alkyl glycol ethers: implications for teratogenicity. Loch-Caruso, Rita; Trosko, James E.; Corcos, Isabel A. (Dep. Pediatr. Hum. Dev., Michigan State Univ., East Lansing, MI 48824, USA). EHP, Environ. Health Perspect., 57, 119-23 (English) 1984. CODEN: EVHPAZ. ISSN: 0091-6765. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Several structurally related alkyl glycol ethers were examd. for their ability to block junction-mediated intercellular communication. Interruption of intercellular communication was measured in vitro by an assay that depends on the transfer of metabolites via gap junctions, i.e., metabolic cooperation. All compds. tested-ethylene glycol (EG) [107-21-1], ethylene glycol monomethyl ether (EGME) [109-86-4], ethylene glycol monoethyl ether (EGEE) [110-80-5], ethylene glycol monopropyl ether (EGPE) [2807-30-9], and ethylene glycol monobutyl ether (EGBE) [111-76-2]-were able to block metabolic cooperation in vitro. The potencies of the compds. were inversely related to the length of the aliph. chain, the dose required for max. blockage increasing as the aliph. chain shortened. Cytotoxicity, as measured by cell survival, was also related to the structure of the compd., generally increasing with increased length of the aliph. chain. The noncytotoxic concn. ranges over which communication was blocked became reduced as the length of the aliph. chain increased. EG with ranges relative to EG and EGME. The remaining compds. had very narrow effective ranges relative to EG and EGME. Because they are effective over such broad noncytotoxic ranges, blockage of intercellular communication may be most significant as a teratogenic mechanism for EG and EGME. Although the other compds. in the series also blocked communication, they were more cytotoxic and they interrupted communication in a relatively narrow window of concns. Consequently, interrupted intercellular communication may be mixed with cytotoxicity in the embryo and the mother, and thus be less specific as a mechanism of teratogenesis for EGEE, EGPE, and EGBE.