Detail of "2812-46-6"

Reference

N-Carboxymethyl-substituted lysyl and a-(e-aminoalkyl)glycyl amino acid antihypertensive agents

N-Carboxymethyl-substituted lysyl and a-(e-aminoalkyl)glycyl amino acid antihypertensive agents. Patchett, Arthur A.; Wu, Mu T. (Merck and Co., Inc. , USA). S. African ZA 8302508 A 28 Nov 1984, 51 pp. (English). (South Rica). CODEN: SFXXAB. CLASS: ICM: A61K. ICS: C07C. APPLICATION: ZA 83-2508 11 Apr 1983. PRIORITY: US 82-367531 12 Apr 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 34 Novel N-carboxymethyl substituted lysyl and a-(e-aminoalkyl)glycyl amino acids, which are inhibitors of angiotensin I-converting enzymes, were formulated in pharmaceutical compns. and used to treat hypertension. 710-11-2 is the cas registry number of certain chemical which is used as reagents here. I was treated with 4-phenyl-2-oxobutanoic acid [710-11-2] to give N-[6-benzyloxycarbonylamino-2-(1-carboxy-3-phenylpropylamino)-5- hydroxyhexanoyl]-L-proline [96359-86-3], and the latter compd. was hydrogenated to give N-[6-amino-2-(1-carboxy-3-phenylpropylamino)-5-hydroxyhexanoyl-L -proline (II) [96359-87-4] which has antihypertensive activity. The synthesis of these amino acids was described. E.g. There are some commonly used reagents like 710-11-2 in this article., 5-hydroxy-L-lysine [1190-94-9] was converted to N-(2-amino-6-benzyloxycarbonylamino-5-hydroxyhexanoyl)-L-proline (I) [96359-85-2] by a series of blocking and deblocking reactions and reaction with L-proline tert-Bu ester [2812-46-6]. Compns. contg. the title compds. and known antihypertensives were described. ..

The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group as a new, nucleophile-resistant protecting group for tyrosine in solid phase peptide synthesis

The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group as a new, nucleophile-resistant protecting group for tyrosine in solid phase peptide synthesis. Rosenthal, Katri; Karlstrom, Amelie; Unden, Anders (Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm S-10691, Swed.). Tetrahedron Letters, 38(6), 1075-1078 (English) 1997 Elsevier. CODEN: TELEAY. ISSN: 0040-4039. 6456-74-2 and 2812-46-6 are also in the experiment. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group is presented as a new protecting group for tyrosine. The Doc group is 1000-fold more stable towards the nucleophile piperidine than the commonly used 2-bromobenzyloxycarbonyl (2-BrZ) group is, and it is completely cleaved by hydrogen fluoride. .