Reference

Preparation of a androsta-1,4-diene-17b-carboxylate with glucocorticosteroid receptor agonist activity for use in pharmaceutical compositions as anti-inflammatory agents

Preparation of a androsta-1,4-diene-17b-carboxylate with glucocorticosteroid receptor agonist activity for use in pharmaceutical compositions as anti-inflammatory agents. Biggadike, Keith; Needham, Deborah (Glaxo Group Limited, UK). PCT Int. Appl. WO 2005005452 A1 20 Jan 2005, 25 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07J003-00. ICS: A61K031-56; A61P005-44. APPLICATION: WO 2004-EP7820 9 Jul 2004. PRIORITY: GB 2003-16290 11 Jul 2003. DOCUMENT TYPE: Patent CA Section: 32 (Steroids) Section cross-reference(s): 1, 63 Androsta-1,4-diene-17b-carboxylate deriv. I was prepd.There are some commonly used reagents with their cas registry numbers 28416-82-2 and 827319-43-7 in this article. for therapeutic use as an anti-inflammatory agent and for use in combination therapy with b2-adrenoreceptor agonists. Thus, I was prepd. via an esterification reaction of the corresponding androsta-1,4-diene-17b-carboxylic acid with BrCH2CN using sodium carbonate in DMF. I was assayed in vitro for glucocorticoid agonist activity and for progesterone receptor activity. .