CAS No.285-69-8,3,4-Epoxytetrahydrofuran Suppliers

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Basic Information

Molecular Structure:
CAS No.:	285-69-8
Name:	3,4-Epoxytetrahydrofuran
Article Data:	28

Formula:	C₄H₆O₂
Molecular Weight:	86.0904
Synonyms:	Furan, 3,4-epoxytetrahydro-;NSC 196231;3,6-Dioxabicyclo[3.1.0]hexane;
EINECS:	206-006-1
Density:	1.237 g/cm³
Boiling Point:	128 °C at 760 mmHg
Flash Point:	31.1 °C
Solubility:	moderately soluble in water
Appearance:	clear yellow liquid
Hazard Symbols:	Xi
Risk Codes:	10-36/37/38
Safety:	16-23-26-36/37/39
PSA:	21.76000
LogP:	-0.21600

Synthetic route

: 1708-29-8
2,5-dihydrofuran

: 285-69-8
3,4-epoxytetrahydrofuran

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran at 0 - 20℃;	84.6%
With mCPHA In dichloromethane at 0 - 20℃;	84.6%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane Heating;	71%

trans-4-chloro-tetrahydro-furan-3-ol: trans-4-chloro-tetrahydro-furan-3-ol

: 285-69-8
3,4-epoxytetrahydrofuran

Conditions

Conditions	Yield
With copper(I) oxide; diisopropylbenzene
With sodium hydroxide
With calcium hydroxide; water

: 285-69-8
3,4-epoxytetrahydrofuran

: 144870-96-2
trans-4-amino-3-hydroxytetrahydrofuran

Conditions

Conditions	Yield
With ammonium hydroxide at 85℃; for 0.5h; microwave irradiation;	100%
With ammonium hydroxide In isopropyl alcohol at 80℃; for 12h;	95%
With ammonia In water; isopropyl alcohol at 80℃; for 12h;	95%
With ammonium hydroxide
With ammonium hydroxide at 100℃; for 14h;

: 285-69-8
3,4-epoxytetrahydrofuran

: 144870-96-2
4-amino-3-hydroxytetrahydrofuran

Conditions

Conditions	Yield
With ammonium hydroxide In isopropyl alcohol at 80℃; for 15h;	100%
With ammonia; water In isopropyl alcohol at 80℃; for 18h;	96.8%
With ammonia In water; isopropyl alcohol at 80℃; for 18h;	96.8%

: 285-69-8
3,4-epoxytetrahydrofuran

: 805250-31-1
4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde

: 4′-(((3R,4R)/(3S,4S)-4-hydroxytetrahydrofuran-3-yl)oxy)-2',6'-dimethylbiphenyl-3-carbaldehyde

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 100℃; for 1.5h; Microwave irradiation;	100%
With potassium carbonate In ethanol at 100℃; for 1.5h; Inert atmosphere; Microwave irradiation;	100%

: 285-69-8
3,4-epoxytetrahydrofuran

: 106-41-2
4-bromo-phenol

: trans-4-(4-bromophenoxy)tetrahydrofuran-3-ol

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; caesium carbonate In 1,4-dioxane for 18h; Reflux; Inert atmosphere;	100%

: 285-69-8
3,4-epoxytetrahydrofuran

: 124-38-9
carbon dioxide

: tetrahydrofuro[3,4-d]1,3-dioxolan-2-one

Conditions

Conditions	Yield
With tetrabutylammomium bromide In neat (no solvent) at 100℃; for 12h; chemoselective reaction;	98%
With C68H105N2O5YZn; tetrabutylammomium bromide In butanone at 70℃; under 7600.51 Torr; for 24h; Temperature; Autoclave;	92%
With C32H24Al2Cl8N2O6*2C4H8O; tetrabutylammomium bromide In neat (no solvent) at 85℃; under 7500.75 Torr; for 40h; Schlenk technique;	89%

: 285-69-8
3,4-epoxytetrahydrofuran

: 501126-38-1
tert-butyl 4-(2-fluoro-4-hydroxyphenyl)piperazine-1-carboxylate

: tert-butyl 4-(2-fluoro-4-((4-hydroxytetrahydrofuran-3-yl)oxy)phenyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane at 100℃; for 16h;	98%

: 285-69-8
3,4-epoxytetrahydrofuran

: 637-87-6
1-Chloro-4-iodobenzene

: benzene 1,3,5-triyl triformate

: C11H10Cl2O3

Conditions

Conditions	Yield
With aluminum (III) chloride; palladium diacetate; triethylamine; triphenylphosphine; lithium chloride In N,N-dimethyl-formamide at 85℃; for 20h; Sealed tube; Inert atmosphere;	96%

...Expand

: 285-69-8
3,4-epoxytetrahydrofuran

: 34813-49-5
t-butylsulfonamide

: (+/-)-N-[(3R,4S)-4-hydroxytetrahydrofuran-3-yl]-tert-butylsulfonamide

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In 1,4-dioxane at 90℃; for 96h;	95%

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Specification

The 3,4-Epoxytetrahydrofuran, with the CAS registry number 285-69-8, has the systematic name of 3,6-dioxabicyclo[3.1.0]hexane. It is a kind of clear yellow liquid, and should be stored at 0-6°C. And the molecular formula of the chemical is C₄H₆O₂.

The physical properties of 3,4-Epoxytetrahydrofuran are as followings: (1)ACD/LogP: -0.46; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.46; (4)ACD/LogD (pH 7.4): -0.46; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 13.36; (8)ACD/KOC (pH 7.4): 13.36; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 21.76 Å²; (13)Index of Refraction: 1.478; (14)Molar Refractivity: 19.7 cm³; (15)Molar Volume: 69.5 cm³; (16)Polarizability: 7.81×10^-24cm³; (17)Surface Tension: 42.9 dyne/cm; (18)Density: 1.237 g/cm³; (19)Flash Point: 31.1 °C; (20)Enthalpy of Vaporization: 35.06 kJ/mol; (21)Boiling Point: 128 °C at 760 mmHg; (22)Vapour Pressure: 13.2 mmHg at 25°C.

You should be cautious while dealing with this chemical. It is a kind of flammable chemical which irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Keep away from sources of ignition - No smoking; Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)SMILES: O1C2COCC12
(2)InChI: InChI=1/C4H6O2/c1-3-4(6-3)2-5-1/h3-4H,1-2H2
(3)InChIKey: AIUTZIYTEUMXGG-UHFFFAOYAN