Detail of "2861-28-1"

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New dopaminergic and potential anti-Parkinson compounds, N,N-disubstituted b-(3,4-dihydroxyphenyl)ethylamines

New dopaminergic and potential anti-Parkinson compounds, N,N-disubstituted b-(3,4-dihydroxyphenyl)ethylamines. Ginos, James Z.; Cotzias, George C.; Doroski, David (Dep. Neurol., Cornell Univ. Med.Several reagents such as 10313-60-7 is used here. 10313-60-7 is the cas registry number. This chemical is also mentioned in this article. Coll., New York, N. Y., USA). J. Med. Chem., 21(2), 160-5 (English) 1978. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 25 Twelve dopamine analogs were prepd. by amidation of 3,4-dimethoxyphenylacetyl chloride [10313-60-7] or 3,4-methylenedioxyphenylacetic acid [2861-28-1], followed by redn. and demethylation, or alternatively by amidation followed by redn. and reductive formylation or acylation and redn., followed by demethylation. The 3 N-propyl-N-substituted homologs were most effective in inducing asym. postures in caudectomized mice, while 2 of these, I [65407-57-0] and II [63925-50-8], caused the greatest no. of turns and longest duration of turning in nigra-lesioned rats. The analog with blocked OH groups, N-propyl-N-butyl-3,4-(methylenedioxy)phenethylamine-HCl [65482-62-4], failed to elicit behavioral effects. Structure-activity relations are discussed. ..