Reference

Raman spectroscopic studies of different forms of cholesterol and its derivatives in th crystalline state

Raman spectroscopic studies of different forms of cholesterol and its derivatives in th crystalline state. Faiman, Rosalind (Lipid Chem. Lab., Univ. Goteborg, Goteborg, Swed.). Chem. Phys.Several reagents with their cas registry numbers 2864-50-8 and 5808-12-8 are used here. Lipids, 18(1), 84-104 (English) 1977. CODEN: CPLIA4. DOCUMENT TYPE: Journal CA Section: 32 (Steroids) Section cross-reference(s): 22, 23 The Raman spectra of the various cholesterols are highly complex. Three regions of the spectrum yield considerable information about the crystalline chain packing in each form. They are: (1) the low frequency region below 300 cm-1, giving information on the inter- and intramol. vibrations in the cholesteryl moiety; (2) the methylene rocking-deformation region between 1400 and 1500 cm-1 giving information on chain packing in the crystalline state, and (3) the C-H stretching region between 2700 and 3100 cm-1 which indicates that there is a correlation between branching in the side chains of the cholesterols, polarity of the substituent groups in the various derivs. studied, and relative chain order in the packing arrangements in the crystalline state. The study of 2 branched chain aerosol derivs., bis(di-2-octyl)sodium sulphosuccinate and bis(di-2-ethylhexyl)sodium sulphosuccinate, indicate that branched chain amphiphiles are good Raman spectroscopic models for the cholesterols, similar to previous Raman spectroscopic studies which have found straight chain amphiphiles to be good models for more complex phospholipids. .