Reference

The Unusual Transformation of an Aromatic 1H-Imidazole into a Non-Aromatic 2H-Imidazole

The Unusual Transformation of an Aromatic 1H-Imidazole into a Non-Aromatic 2H-Imidazole. de la Hoz, Antonio; Sanchez-Migallon, Ana; Mateo, Maria del Carmen; Prieto, Pilar; Infantes, Lourdes; Elguero, Jose (Departamento de Quimica Inorganica, Organica y Bioquimica, Facultad de Ciencias Quimicas, Universidad de Castilla-La Mancha, Ciudad Real E-13071, Spain). Structural Chemistry, 16(5), 485-490 (English) 2005 Springer Science+Business Media, Inc. CODEN: STCHES. ISSN: 1040-0400.There are some reagents like 90052-22-5 is used in this study. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) Section cross-reference(s): 75 2H-Imidazole deriv. I has been synthesized and characterized by the X-ray diffraction (XRD) method. The compd. crystallizes in the monoclinic space group Cc with cell parameters a = 19.398(1), b = 8.890(1), c = 10.247(1), b = 110.76(1), Z = 4. The mols. are inter-linked through C-H×××O and C-H×××p interactions forming infinite chains. .

Organogels from 1H-Imidazole Amphiphiles: Entrapment of a Hydrophilic Drug into Strands of the Self-Assembled Amphiphiles

Organogels from 1H-Imidazole Amphiphiles: Entrapment of a Hydrophilic Drug into Strands of the Self-Assembled Amphiphiles. Seo, Sang Hyuk; Chang, Ji Young (School of Materials Science and Engineering, and Hyperstructured Organic Materials Research Center, College of Engineering, Seoul National University, Seoul 151-742, S. Korea). Chemistry of Materials, 17(12), 3249-3254 (English) 2005 American Chemical Society. CODEN: CMATEX. ISSN: 0897-4756. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Linear 1H-imidazole amphiphiles (1-3) were synthesized by the esterification reaction of 4'-alkyloxy phenol with 4-chlorocarbonyl imidazole. They formed organogels. When 1N of the imidazole head was blocked by an Et group, however, the compd. (4) did not self-assemble. The SAX and TEM study revealed that in a dry gel state, the 1H-imidazole amphiphiles self-assembled into a fibrous aggregate having a reverse micellar cubic structure. Norfloxacin (NFLX), a fluorescent hydrophilic antibiotic, showed relatively weak fluorescence emission in THF/n-hexane (10-6 mol/mL) when excited at 280 nm. In the organogel of compd. 3 (1.5 wt %) in THF/n-hexane, integrated fluorescence intensity of NFLX was enhanced approx. 10 times as compared to that in the THF/n-hexane soln. or sol state, strongly suggesting that NFLX was trapped in the hydrophilic core of a micellar assembly of compd. 3. The dry gel fibers were also strongly fluorescent under confocal laser scanning microscopy.