Detail of "28911-01-5"

CAS Number:
28911-01-5
Name:
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-(2-chlorophenyl)-1-methyl-
Superlist Name:
Triazolam
Molecular Structure:
Formula:
C17H12 Cl2 N4
Molecular Weight:
343.21
Synonyms:
4H-s-Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-(o-chlorophenyl)-1-methyl- (8CI);8-Chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine; DII-18-2; Halcion; Novodorm; Songar; Triazolam; U 33030
EINECS:
249-307-3
Density:
1.46 g/cm³
Boiling Point:
535.6 °C at 760 mmHg
Flash Point:
277.7 °C
Solubility:
soluble in alcohol and poorly soluble in water.
Appearance:
white crystalline powder
Hazard Symbols:
TF
Risk Codes:
11-23/24/25-36/38-39/23/24/25
Safety:
22-24/25-26-36-45-36/37-16-7 Details

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Drug analyses by polarography: Drug analyses by polarography. Part 23. Polarographic determination (DPP and CRP) of triazolam in plasma and serum. Oelschlaeger, Herbert; Senguen, Inci F. (Inst. Pharm. Chem., Johann Wolfgang Goethe-Univ., Frankfurt am Main D-6000, Fed. Rep. Ger.). Arch. Pharm. (Weinheim, Ger.), 317(1), 69-73 (German) 1984. CODEN: ARPMAS. ISSN: 0365-6233. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 Triazolam (I) [28911-01-5], added to human plasma together with DMF as solubilizer, was mixed with buffer at pH 39 (HBO3-KCl-NaOH buffer), placed on a fresh Extrelut column, and extd. with PhMe. The solvent was evapd. to dryness, the residue taken up in acetate buffer (pH 4) plus DMF, and I detd. by differential pulsed polarog. (DPP or cathode ray polarog. (CRP). The peak potential of I was -0.8 V. The recovery rate was >90% and the detection limit was 30-40 mg/mL. The method is suitable for use in cases of I overdose.

Comparative pharmacokinetics of brotizolam and triazolam in healthy subjects: Comparative pharmacokinetics of brotizolam and triazolam in healthy subjects. Jochemsen, Roeline; Wesselman, J. G. J.; Van Boxtel, C. J.; Hermans, J.; Breimer, D. D. (Subfac. Pharm., Univ. Leiden, Leiden 2300 RA, Neth.). Br. J. Clin. Pharmacol., 16(Suppl. 2), 291-7 (English) 1983. CODEN: BCPHBM. ISSN: 0306-5251. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Pharmacokinetic studies in healthy young volunteers reveal that the plasma concn. profile of brotizolam [57801-81-7] can be described as a 1-compartmental open model with 1st-order absorption, whereas the absorption of triazolam [28911-01-5] was less regular and in half of the subjects was not consistent with 1st-order kinetics. Interindividual variability in absorption rate (peak times) was larger for brotizolam. Mean peak times were 1.1 h for brotizolam and 1.2 h for triazolam and mean peak concns. were 7.3 ng/mL and 5.0 ng/mL, resp. The elimination half-life of brotizolam was twice that of triazolam with mean values of 5.0 h and 2.6 h, resp. There was no correlation between the half-lives of the 2 drugs. Protein unbound fraction was similar for triazolam and brotizolam with mean values of 9.9% and 8.4%, resp.