Detail of "2894-67-9"

CAS Number:
2894-67-9
Name:
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-
Superlist Name:
Delorazepam
Molecular Structure:
Formula:
C₁₅H₁₀Cl₂N₂O
Molecular Weight:
305.16
Synonyms:
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro- (7CI,8CI);2'-Chloronordiazepam;7-Chloro-1,3-dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiazepin-2-one;7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one;7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Chlordemethyldiazepam;Chlordesmethyldiazepam;Chlorodesmethyldiazepam;NSC 169895;RV 12165;Ro 5-3027;
EINECS:
220-771-9
Density:
1.42 g/cm³
Melting Point:
187-189 °C
Boiling Point:
481.7 °C at 760 mmHg
Flash Point:
245.1 °C
Appearance:
Off-white to light yellow solid
Hazard Symbols:
Xn, T, F
Risk Codes:
22-39/23/24/25-23/24/25-11
Safety:
36/37/39-45-36/37-16 Details
Transport Information:
UN 1230 3/PG 2

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On the hypnogenic and anticonvulsant activities of demethyldiazepam and chlordemethyldiazepam: time-effect relations: On the hypnogenic and anticonvulsant activities of demethyldiazepam and chlordemethyldiazepam: time-effect relations. Traversa, U.; De Angelis, L.; Vertua, R. (Inst. Pharmacol., Univ. Trieste, Trieste, Italy). J. Pharm. Pharmacol., 29(8), 504-6 (English) 1977. CODEN: JPPMAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Sleep-inducing activity of demethyldiazepam (I) [1088-11-5] or chlordemethyldiazepam (II) [2894-67-9] given in combination with hexobarbitone (100 mg/kg, i.p.) reached a peak 60 min after administration; at 24 h activity of I and II was reduced to 10 and 25% resp. of that obsd. at 60 min. I and II had similar sleep-inducing activity when given in combination with chlorprothixene which peaked at 60 min. In antileptazol tests, I and II protected against mortality and convulsions maximally at 60 min; at 24 h activity of I and II was 12.5 and 33.3% resp. of that at 60 min. Thus II was more effective than I.

Hydroxylation of three benzodiazepines in vitro: Hydroxylation of three benzodiazepines in vitro. Mussini, E.; Marcucci, F.; Airoldi, L.; Facchinetti, T.; Garattini, S. (Ist. Ric. Farmacol. "Mario Negri", Milan, Italy). J. Pharm. Sci., 66(10), 1482-3 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Three structurally related benzodiazepines were studied as substrates for hydroxylation by liver microsomal enzymes of rats and mice. The Vmax was comparable for dechlorodesmethyldiazepam (I) [2898-08-0], desmethyldiazepam (II) [1088-11-5] and 2'-chlorodesmethyldiazepam (III) [2894-67-9] in the 2 animals species. The apparent Km decreased from I to III for liver microsomal enzymes from both animal species. The hydroxylation of II and III yielded two pharmacol. active metabolites, oxazepam [604-75-1] and lorazepam [846-49-1], resp.