Detail of "2899-66-3"

Reference

Amino acids and peptides

Amino acids and peptides. CXC. Oxytocin analogs with inhibitory properties, containing in position 2 a hydrophobic amino acid of D-configuration. Lebl, Michal; Barth, Tomislav; Servitova, Linda; Slaninova, Jirina; Jost, Karel (Inst. Org. Chem. Biochem., Czech. Acad. Sci., Prague 166 10/6, Czech.). Collect. Czech. Chem. Commun., 50(1), 132-45 (English) 1985. CODEN: CCCCAK. ISSN: 0366-547X. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 2 Oxytocin analogs I [R = R1 = H, X = SCH2, X1 = D-Tyr, D-Phe, D-Phe(Me), Phe(Et), D-Phe(Et), D-Tyr(Et); R = R1 = H, X = SOCH2, X1 = D-Phe(Et); R = NH2, H, R1 = H, X = SS, X1 = D-Phe(Et); R = NH2, R1 = Me, X = SS, X1 = Phe(Et), D-Phe(Et)] were prepd. by conventional soln. methods and their biol. activities were detd. A combination of 2 structural features which alone lead to strong inhibitors (a suitable D-amino acid in position 2 and a penicillamine moiety in position 1) did not enhance the inhibitory effect.In this experiment, several chemicals are used like 2899-66-3 I contg. D-Tyr are weak agonists in the uterotonic assay, whereas analogs with D-Phe substituted in the para position are the most potent antagonists of the uterotonic effect of oxytocin. .