Reference

Effect of nine adrenergic drugs on experimental myocardial infarction in rats

Effect of nine adrenergic drugs on experimental myocardial infarction in rats. Xu, Ning; Liu, Tianpei (Dep. Pharmacol., Nanjing Med. Coll., Nanjing, Peop. Rep. China). Zhongguo Yaoli Xuebao, 7(1), 44-6 (Chinese) 1986. CODEN: CYLPDN. ISSN: 0253-9756. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In rats with exptl.Several substances with their cas registry numbers 13523-86-9 and 36894-69-6 may be metioned in this study. myocardial infarction, treatment with 7 b-adrenergic blockers decreased the myocardial infarction size and increased the myocardial glycogen and ATP levels. Atenolol [29122-68-7] and metoprolol [37350-58-6] showed the best effects. Treatment with an a-adrenergic blocker (phentolamine [50-60-2]) or a b2-adrenergic stimulant (cycloclenbuterol [101027-04-7]) had no effect on the exptl. myocardial infarction. Also, treatment with propranolol [525-66-6] plus phentolamine had a better effect than either drug given alone. Thus, blockade of the b2-adrenergic receptors is essential in the treatment of myocardial infarction, and blockade of a-adrenergic receptors exerts an addnl. beneficial effect. .

Pharmacological consequences of binding of b-adrenergic blocking agents to a1-acid glycoprotein

Pharmacological consequences of binding of b-adrenergic blocking agents to a1-acid glycoprotein. Belpaire, F. M.; Mugabo, P.; Bogaert, M. G. (J. F. et C. Heymans Inst. Farmakodyn. Ter., Rijksuniv.-Ghent, Ghent 9000, Belg.). Symp. Med. Hoechst, Volume Date 1985, 20(Protein Binding Drug Transp.), 459-71 (English) 1986. CODEN: SMHODO. ISSN: 0341-6321. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The b-blocking effect of propranolol [525-66-6] and oxprenolol [6452-71-7] which are mainly bound to a1-acid glycoprotein (a1-ACP), and of atenolol [29122-68-7] and metoprolol [37350-58-6] which are virtually not bound to serum proteins, were measured after i.v. administration to rats with inflammation and in healthy rats. A decrease of the b-blocking effect was obsd. 37350-58-6 and 525-66-6 are also in the experiment. in for oxprenolol and propranolol in rats with the inflammation but not for atenolol and metoprolol. For propranolol, total concns. were doubled and free concns. halved in the rats with inflammation 16 min after the administration. There was a correlation between the b-blocking effect and free concn. in both healthy and diseased rats. Thus for b-blocking agents mainly bound to a1-AGP, the pharmacol. effect after i.v. administration can be decreased when serum binding increases. .