Detail of "2932-65-2"

Reference

Bis(6-oxopyridazinyl)benzene derivatives as drugs

Bis(6-oxopyridazinyl)benzene derivatives as drugs. Prain, Hunter Douglas; Warrington, Brian Herbert (Smith Kline and French Laboratories Ltd., UK). Eur. Pat. Appl. EP 208517 A2 14 Jan 1987, 28 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (European Patent Organization) CODEN: EPXXDW. CLASS: ICM: C07D237-14. ICS: C07D237-04; A61K031-50. APPLICATION: EP 86-305187 4 Jul 1986. PRIORITY: GB 85-17051 5 Jul 1985; GB 86-6853 20 Mar 1986. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds. (I; R1, R2 = H, Me; dotted lines = optional double bonds; the benzene ring is m- or p-substituted) were prepd. as phosphodiesterase inhibitors, useful in treating congestive heart failure. C6H4(COMe)2-1,4 condensed with HCOCO2H to give 1,4-(HO2CCH:CHCO)2C6H4 which cyclocondensed with N2H4 to give I (R1 = R2 = H, dotted line = bond, p-substituted) (II). In cats 0.04 mmol II/kg increased left ventricular contractility 50%. Capsules were prepd.There are some commonly used reagents with their cas registry numbers 2932-65-2 and 17558-64-4 in this article. contg. active ingredient 0.5, soya lecithin/soybean oil 90.45, hydrogenated vegetable oil/beeswax 9.05%. .

Method for preparation of 2-arylimidazo[2,1-a]isoquinoline

All Rights Reserved. Method for preparation of 2-arylimidazo[2,1-a]isoquinoline. Shang, Zhicai; Luo, Chengcai (Zhejiang University, Peop. Rep. China). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1872855 A 6 Dec 2006, 7pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. 67-68-5 and 2932-65-2 which are cas registry numbers are also used here. APPLICATION: CN 2010-52180 29 Jun 2006. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) 2-Arylimidazo[2,1-a]isoquinoline I (R1 = H, Me; R2 = Me, pr-n) was prepd. substituted benzene reacted with acetyl chloride via Friedel-Crafts reaction to obtain the corresponding substituted acetophenone, then bromination to form a-bromo-substituted acetophenone; On the other hand nitration isoquinoline with potassium nitrite to give 1-nitroisoquinoline, then redn. with Raney nickel to form 1-aminoisoquinoline; Finally, cyclization of the obtained two compds. to provide the title products. This method has the advantages of simple process and low requirements for app., and easy for industrialization. .