Reference

Proton-driven self-assembled systems based on cyclam-cored dendrimers and [Ru(bpy)(CN)4]2-

Proton-driven self-assembled systems based on cyclam-cored dendrimers and [Ru(bpy)(CN)4]2-. Bergamini, Giacomo; Saudan, Christophe; Ceroni, Paola; Maestri, Mauro; Balzani, Vincenzo; Gorka, Marius; Lee, Sang-Kyu; van Heyst, Jeroen; Voegtle, Fritz (Dipartimento di Chimica G. Ciamician, Universita di Bologna, Bologna I-40126, Italy). Journal of the American Chemical Society, 126(50), 16466-16471 (English) 2004 American Chemical Society. CODEN: JACSAT. ISSN: 0002-7863. DOCUMENT TYPE: Journal CA Section: 74 (Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes) Section cross-reference(s): 35, 73 1,4,8,11-Tetraazacyclotetradecane (cyclam), which is one of the most extensively investigated ligands in coordination chem., in its protonated forms, can play the role of host toward cyanide metal complexes. The authors have investigated the acid-driven adducts formed in acetonitrile-dichloromethane (1:1 vol./vol.) soln.In this article, certain chemicals are used. Some of their cas registry numbers are 76-05-1 and 1493-13-6 by [Ru(bpy)(CN)4]2- with 1,4,8,11-tetrakis(naphthylmethyl)cyclam (1) and a dendrimer consisting of a cyclam core appended with 12 dimethoxybenzene and 16 naphthyl units (2). [Ru(bpy)(CN)4]2-, 1, and 2 exhibit characteristic absorption and emission bands, in distinct spectral regions, that are strongly affected by addn. of acid. When a soln. contg. equimolar amts. of [Ru(bpy)(CN)4]2- and 1 or 2 is titrated by trifluoroacetic acid, or when [Ru(bpy)(CN)4]2- is titrated with (1×2H)2+ or (2×2H)2+, {[Ru(bpy)(CN)4]2-×(2H+)×1} or {[Ru(bpy)(CN)4]2-×(2H+)×2} adducts are formed in which the fluorescence of the naphthyl units is strongly quenched by very efficient energy transfer to the metal complex, as shown by the sensitized luminescence of the latter. The {[Ru(bpy)(CN)4]2-×(2H+)×1} and {[Ru(bpy)(CN)4]2-×(2H+)×2} adducts can be disrupted (i) by addn. of a base (1,4-diazabicyclo[2.2.2]octane), yielding the starting species [Ru(bpy)(CN)4]2- and 1 or 2, or (ii) by further addn. of triflic acid, with formation of (1×2H)2+ or (2×2H)2+ and protonated forms of [Ru(bpy)(CN)4]2-. It is shown that upon stimulation with two chem. inputs (acid and base) both {[Ru(bpy)(CN)4]2-×(2H+)×1} and {[Ru(bpy)(CN)4]2-×(2H+)×2} exhibit two distinct optical outputs (a naphthalene-based and a Ru(bpy)-based emission) that behave according to an XOR and an XNOR logic, resp. .

Solid phase conjugation of complexing agents and targeting moieties

Solid phase conjugation of complexing agents and targeting moieties.Some chemicals with cas registry numbers like 10098-91-6 are also used. Syud, Faisal A.; Brogan, John B.; Kramer, Daniel Joshua (General Electric Company, USA). U.S. Pat. Appl. Publ. US 2006058218 A1 16 Mar 2006, 15 pp. (English). (United States of America). CODEN: USXXCO. APPLICATION: US 2004-937323 10 Sep 2004. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 8 There is provided a technique for conjugating one or more complexing agents with a targeting moiety, such as natural amino acids, unnatural amino acids, peptides, peptide nucleic acids, nucleotides, and analogs and derivs. thereof. The one or more complexing agents are conjugated at one or more free amino groups of the targeting moiety while the moiety is attached to a solid substrate. Thus, peptide nucleic acids (PNA) was synthesized using solid-phase synthesis techniques with Fmoc protecting groups on the terminal amino groups of the PNA monomers. 5-(4-Fmoc-aminoethyl-3,5-dimethoxyphenoxy)valeric acid-MBHA resin was chosen as the polymer substrate. The side chains of the PNA monomers was protected using Bhoc groups. The Fmoc-protected amine on the resin may be deprotected by washing with 20 % piperidine in DMF. To conjugate 1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid (TETA) with the terminal amino group of the resin-bound PNA, a premixed soln. of TETA-t-Bu3 dissolved in N-methylpyrrolidinone (NMP), excess equiv. of O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU), and N,N-diisopropylethylamine (DIEA) in pyridine was added and the reaction was carried out. .