Reference

Changes in ventilation, breathing pattern and acid-base balance of conscious rabbits following intravenous almitrine

Changes in ventilation, breathing pattern and acid-base balance of conscious rabbits following intravenous almitrine. Maskrey, M. (Dep. Physiol., Univ. Tasmania, Hobart 7001, Australia). Aust. J. Exp. Biol. Med. Sci., 64(4), 389-95 (English) 1986. CODEN: AJEBAK. ISSN: 0004-945X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In conscious rabbits, a single injection of almitrine bismesylate [29608-49-9] via a marginal ear vein caused an immediate increase in ventilation through an increase in tidal vol. (VT), frequency (f) showing a small decline. After 15 min, f was increased to above control level and VT declined. Slower, deeper breathing was reinstated by 40 min postinjection. Large changes in blood gases occurred in the 1st 15 min, with PO2 raised by 30 Torr and PCO2 lowered by 20 Torr. These recovered to be within 10 and 7.5 Torr, resp., of control at the end of 1 h. Blood lactate [50-21-5] concn. was increased steeply at 1st, then declined towards control levels. The acid-base situation was mixed, comprising a respiratory alkalosis, resulting from CO2 washout, and a metabolic acidosis from high lactate concn. These results are discussed in the context of assessing the primary and secondary effects of almitrine and recognition of the possibility that the drug may act at more than one site to alter respiration.

Clinical pharmacokinetics of almitrine bismesylate

Clinical pharmacokinetics of almitrine bismesylate. Bromet, N.; Singlas, E. (Orleans F 45000, Fr.). Presse Med., 13(34), 2071-7 (French) 1984. CODEN: PRMEEM. ISSN: 0755-4982. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review with 8 refs. on the pharmacokinetics of almitrine bismesylate [29608-49-9] in healthy subjects and patients.