Reference

Preparation of trans-cyclohexanecarboxaldehydes and related compounds via fluoride anion catalyzed isomerization

Preparation of trans-cyclohexanecarboxaldehydes and related compounds via fluoride anion catalyzed isomerization. Poetsch, Eike; Jaehrling, Kai; Eckstein, Juergen; Schwarz, Michael ( Merck Patent G.m.b.H.Chemical with cas number 2967-66-0 also plays role., Germany). Ger. Offen. DE 102005034067 A1 23 Feb 2006, 10 pp. (German). (Germany).Several reagents such as 2967-66-0 is used here. CODEN: GWXXBX. APPLICATION: DE 2005-102005034067 21 Jul 2005. PRIORITY: DE 2004-102004039278 13 Aug 2004. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) Section cross-reference(s): 21, 75 A process for the trans-enrichment of title compds. I [R1 = CHO, CN, CO2R2; R2 = alkyl, allyl, aralkyl; X = (A)n; A = (un)substituted 1,4-cycloalkylene with provisos; n = 0-2; Y = halo, (CF2)mR3, etc.; R3 = H, F, Cl, etc.; m = 0-6] was disclosed. For example, DIBAL mediated redn. of 4-(trifluoromethyl)cyclohexanecarboxylic acid Me ester in the presence of KF afforded trans-cyclohexanecarboxaldehyde in 83% yield. Of note, the disclosed process avoids the use of strong bases. i.e., potassium tert-butylate. ..

Preparation of trans-cyclohexanecarboxaldehydes and related compounds via fluoride anion catalyzed isomerization

Preparation of trans-cyclohexanecarboxaldehydes and related compounds via fluoride anion catalyzed isomerization. Poetsch, Eike; Jaehrling, Kai; Eckstein, Juergen; Schwarz, Michael ( Merck Patent G.m.b.H.Chemical with cas number 2967-66-0 also plays role., Germany). Ger. Offen. DE 102005034067 A1 23 Feb 2006, 10 pp. (German). (Germany).Several reagents such as 2967-66-0 is used here. CODEN: GWXXBX. APPLICATION: DE 2005-102005034067 21 Jul 2005. PRIORITY: DE 2004-102004039278 13 Aug 2004. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) Section cross-reference(s): 21, 75 A process for the trans-enrichment of title compds. I [R1 = CHO, CN, CO2R2; R2 = alkyl, allyl, aralkyl; X = (A)n; A = (un)substituted 1,4-cycloalkylene with provisos; n = 0-2; Y = halo, (CF2)mR3, etc.; R3 = H, F, Cl, etc.; m = 0-6] was disclosed. For example, DIBAL mediated redn. of 4-(trifluoromethyl)cyclohexanecarboxylic acid Me ester in the presence of KF afforded trans-cyclohexanecarboxaldehyde in 83% yield. Of note, the disclosed process avoids the use of strong bases. i.e., potassium tert-butylate. ..