Reference

Investigation of the liver glycogen level in rats treated with anticonceptives

Investigation of the liver glycogen level in rats treated with anticonceptives. Marczell, E.; Csak, S. (Pharmacol. Dep., Natl. Inst. Pharm., Budapest, Hung.). Arzneim.-Forsch., 27(6), 1185-8 (English) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In rats treated with mestranol (I) [72-33-3], norethynodrel (II) [68-23-5], or Infecundin [8015-30-3] there was a marked increase in liver glycogen [9005-79-2] level in comparison with controls. A similar, though smaller increase in liver glycogen was obsd. after treatment with ethynodiol diacetate [297-76-7], ethynylestradiol [57-63-6], or Bisecurin [8075-78-3]. In rats treated with Indecundin for 28 days followed by 5 days withdrawal of treatment, there was still an elevation of liver glycogen, whereas in rats similarly treated with Bisecurin the elevation in liver glycogen disappeared upon 5 days withdrawal of treatment. Apparently, both estrogen and gestagen components of oral contraceptives influence glycogen metab.

Contribution of functional groups of 19-nor-progestogens to binding to progesterone and 17

Contribution of functional groups of 19-nor-progestogens to binding to progesterone and 17.beta.-estradiol receptors in rabbit uterus. Tamaya, Teruhiko; Nioka, Suminori; Furuta, Norio; Shimura, Tatsuoki; Takano, Noboru; Okada, Hiroji (Dep. Obstet. Gynecol., Kyoto Prefect. Univ. Med., Kyoto, Japan). Endocrinology (Philadelphia), 100(6), 1579-84 (English) 1977. CODEN: ENDOAO. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The structural elements of 19-norprogestogens which may be essential for binding to progesterone (I) [57-83-0] and estradiol (II) [50-28-2] receptors were investigated in the rabbit uterine cytosol. 19-Norprogestogens were competitive inhibitors of I-receptor (8 S) binding and II-receptor binding. The affinities of steroids for the I receptor were as follows: norethindrone [68-22-4] 5.alpha.-dihydronorethindrone [52-79-9] > norethindrone acetate [51-98-9] > lynestrenol [52-76-6] > 17.alpha.-ethynylestr-4-ene-3.beta.,17.beta.-diol [1231-93-2] > ethynodiol diacetate [297-76-7]. The affinities of steroids for the II receptor were as follows: ethynodiol diacetate > 17.alpha.-ethynylestr-4-ene-3.beta.,17.beta.-diol > norethindrone acetate > norethindrone > 5.alpha.-dihydronorethindrone > lynestrenol. Apparently, 3-ketone and 17.beta.-hydroxyl groups, and the plane of ring A/B of 19-norprogestogen are important for binding to the I receptor, whereas the affinities for the II receptor are increased with addn. of acetate or hydroxyl groups at the 3.beta. and 17.beta. positions, and are decreased by the elimination of a 3 O function or the redn. of ring A.