Reference

Use of Oxyresveratrol as a neuroprotectant

Use of Oxyresveratrol as a neuroprotectant. Lorenz, Peter; Horn, Thomas; Wolf, Gerald (Germany ). Ger. Offen.Chemicals with cas numbers 29700-22-9 and 67-68-5 also play role. DE 10230961 A1 12 Feb 2004,15 pp. (German). (Germany). CODEN: GWXXBX. CLASS: ICM: A61K035-78. APPLICATION: DE 2002-10230961 10 Jul 2002. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 63 A substance shall be found, which reduces as much as possible oxidative/nitrosative cell stress (e.g. free radicals) for use in therapy and prophylaxis of diseases and functional problems of the nervous system. The substance shall be as produced as economically as possible, isolatable from natural raw materials and easily sol. in aq. media, in order to ensure a stable active substance formulation and a simple application. The use of Oxyresveratrol is suggested, isolated from wood of the white mulberry tree for treatment or prevention of diseases and functional problems of the nervous system. Effectiveness has been exptl. proven on the basis of different nervous system damage models. Based on the excellent antioxidative effect of these substances as neuroprotectants, they can be used esp. for treatment and prophylaxis of strokes and other conditions caused by oxidative/nitrosative stress. .

Neuroprotective effect of oxyresveratrol from Smilacis chinae rhizome on amyloid b protein (25-35)-induced neurotoxicity in cultured rat cortical neurons

All Rights Reserved. Neuroprotective effect of oxyresveratrol from Smilacis chinae rhizome on amyloid b protein (25-35)-induced neurotoxicity in cultured rat cortical neurons. Ban, Ju-Yeon; Jeon, So-Young; Nguyen, Thi Thuy Ha; Bae, KiHwan; Song, Kyung-Sik; Seong, Yeon Hee (College of Veterinary Medicine and Research Institute of Herbal Medicine, Chungbuk National University, Cheongju 361-763, S. Korea). Biological & Pharmaceutical Bulletin, 29(12), 2419-2424 (English) 2006 Pharmaceutical Society of Japan. CODEN: BPBLEO. ISSN: 0918-6158. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) We previously reported that Smilacis chinae rhizome inhibits amyloid b protein (25-35) (Ab (25-35))-induced neurotoxicity in cultured rat cortical neurons. The present study evaluated the neuroprotective effect of oxyresveratrol isolated from Smilacis chinae rhizome against Ab (25-35)-induced neurotoxicity on cultured rat cortical neurons. Oxyresveratrol over the concn. range of 1-10 mM significantly inhibited 10 mM Ab (25-35)-induced neuronal cell death, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. Oxyresveratrol (10 mM) inhibited 10 mM Ab (25-35)-induced elevation of cytosolic calcium concn. ([Ca2+]c), which was measured by a fluorescent dye, Fluo-4 AM. Oxyresveratrol (1, 10 mM) also inhibited glutamate release into medium and reactive oxygen species (ROS) generation induced by 10 mM Ab (25-35). These results suggest that oxyresveratrol prevents Ab (25-35)-induced neuronal cell damage by interfering with the increase of [Ca2+]c, and then by inhibiting glutamate release and ROS generation. Furthermore, these effects of oxyresveratrol may be assocd. 29700-22-9 is just another one chemical used in this study. with the neuroprotective effect of Smilacis chinae rhizome. .