Detail of "2975-41-9"

CAS Number:
2975-41-9
Name:
1H-Inden-2-amine,2,3-dihydro-
Superlist Name:
Indan-2-amine
Molecular Structure:
Formula:
C₉H₁₁N
Molecular Weight:
133.19
Synonyms:
2-Indanamine(6CI,7CI,8CI);(2,3-Dihydro-1H-inden-2-yl)amine;2,3-Dihydro-1H-inden-2-amine;2-Amino-2,3-dihydro-1H-indene;2-Aminoindan;2-Aminoindane;2-Indanylamine;Su8629;
EINECS:
221-021-3
Density:
1.056 g/cm³
Boiling Point:
226.2 °C at 760 mmHg
Flash Point:
96.8 °C
Hazard Symbols:
Xi, C, Xn
Risk Codes:
36/37/38-20/21/22
Safety:
26-36 Details

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Reference

The effects of phenylpropanolamine and other sympathomimetics on food consumption and motor activity in mice: The effects of phenylpropanolamine and other sympathomimetics on food consumption and motor activity in mice. Cairns, M. J.; Foldys, Janet E.; Rees, J. M. H. (Dep. Pharmacol. Mater. Med. Ther., Univ. Manchester, Manchester M13 9PT, UK). J. Pharm. Pharmacol., 36(10), 704-6 (English) 1984. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of phenylpropanolamine [14838-15-4] on motor activity and on food intake were compared with those of (S)-amphetamine [51-64-9], ephedrine [299-42-3], 2-aminoindane [2975-41-9], and fenfluramine [458-24-2] in mice. Motor activity was addnl. measured in mice pretreated with levodopa and benserazide, and food intake in mice pretreated with a-methyl-p-tyrosine. Amphetamine (2.5 mg/kg) increased motor activity, phenylpropanolamine (10-40 mg/kg) and 2-aminoindane (2.5-10 mg/kg) decreased activity whilst ephedrine (2.5-40 mg/kg) had a biphasic effect. Fenfluramine (10-40 mg/kg) had negligible effect on activity. In mice pretreated with levodopa and benserazide both phenylpropanolamine and 2-aminoindane caused a massive increase in motor activity whilst fenfluramine's action was not affected in the same way. Whereas the anorectic action of fenfluramine was considerably potentiated in mice pretreated with a-methyl-p-tyrosine, that of amphetamine, ephedrine, 2-aminoindane and phenylpropanolamine was either unaffected or initially antagonized. Thus, the mechanisms of motor and anorectic actions of phenylpropanolamine are similar to those of amphetamine.

Antinociceptive and sympathomimetic activities of exo- and endo-2-aminobenzonorbornene and their N-methylated derivatives: Antinociceptive and sympathomimetic activities of exo- and endo-2-aminobenzonorbornene and their N-methylated derivatives. Burn, P.; Crooks, P.Several substances are used for example 62594-25-6 and 62624-28-6 which are their cas registry numbers. A.; Rees, J. M. H. (Dep. Pharm., Univ. Manchester, Manchester, Engl.). J. Pharm. Pharmacol., 28, Suppl. 80P (English) 1976. CODEN: JPPMAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Both exo- (I) [62624-26-4] and endo-2-aminobenzonorbornene (II) [58742-04-4] had sympathomimetic activity in rat anococcygeus muscle, but were .apprx.25 less potent than amphetamine [300-62-9] or 2-aminoindane [2975-41-9]. The N-Me deriv. of I had a similar potency to I and II whereas the N-Me deriv. of II and the N,N-di-Me derivs. of both I and II were inactive at 10.mu.g/mL. In the writhing test for antinociceptivity, in which both amphetamine and aminoindane had ED50 values <1 mg/kg, neither I nor II nor their N,N-di-Me derivs. were inhibitory at 5 mg/kg. In contrast, the N-Me derivs. of I and II caused dose-dependent inhibition of writhing with ED50 values of 3.7 and 4.7 mg/kg, resp. .

Detail of "2975-41-9"

1H-Inden-2-amine,2,3-dihydro-

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