Detail of "2979-19-3"

Reference

Potential inhibitors of collagen biosynthesis

Potential inhibitors of collagen biosynthesis. 5,5-Difluoro-DL-lysine and 5,5-dimethyl-DL-lysine and their activation by lysyl-tRNA ligase. Shirota, Frances N.; Nagasawa, Herbert T.; Elberling, James A. (Med. Res. Lab., VA Hosp., Minneapolis, Minn., USA). J.Some chemicals with cas registry numbers like 64442-18-8 are also used. Med. Chem., 20(12), 1623-7 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 34 5,5-Difluoro-DL-lysine [52683-82-6] was prepd. from 2-(acetylamino)-2-(4-amino-3-hydroxybutyl)propanedioic acid di-Et ester acetate salt [63665-79-2] by phthaloylation, oxidn. of the hydroxy group, fluorination, and hydrolysis. 5,5-Dimethyl-DL-lysine-HCl [64442-11-1] was prepd. from 3,3-dimethylcyclohexanone [2979-19-3] by oximation, Beckmann rearrangement, sepn. of the resulting lactams by fractional crystn., chlorination, nucleophilic displacement of the chloro group with NaN3, hydrogenation, and hydrolysis. The difluoro deriv. stimulated the lysine-dependent ATP-PPi exchange reaction in the presence of lysyl-tRNA ligase, in vitro, at a Km 1000-fold higher than L-lysine. The dimethyl deriv. did not stimulate exchange, but, at high concns., was a competitive inhibitor of lysine. The difluoro deriv. had no effect on the incorporation of lysine or proline into proteins in a collagen secreting L-929 fibroblast system, but was slightly inhibitory toward peptidyl lysine hydroxylase [9059-25-0]. .

The reaction of lead tetraacetate with alkyl cyclohexanone

The reaction of lead tetraacetate with alkyl cyclohexanone. Part 2. The formation of .alpha.-acetoxy ketones. Mihailovic, Mihailo Lj.; Jeremic, Dragoslav; Cekovic, Zivorad; Bosnjak, Jovan; Andrejevic, Vladimir (Fac. Sci., Univ. Belgrade, Belgrade, Yugoslavia). Glas. Hem. Drus., Beograd, 41(1-2), 17-28 (English) 1976. CODEN: GHDBAX. DOCUMENT TYPE: Journal CA Section: 24 (Alicyclic Compounds) Section cross-reference(s): 22 Oxidn. of mono-, di-, or trialkylcyclohexanones (or the corresponding cyclohexanols) with Pb(OAc)4 gave the corresponding .alpha.-acetoxycyclohexanones, the structures and stereochem. of which were detd. on the basis of NMR data.There are some commonly used reagents with their cas registry numbers 932-01-4 and 2979-19-3 in this article. 2-Alkyl- and 3-alkylcyclohexanones are acetoxylated preferentially at C-6 position. When .alpha.-acetoxylation can give cis-trans pairs of diastereoisomers, those epimers are formed in excess, which result from axial attack of the acetoxy group on the substrate. These results are rationalized in terms of differences in stability and of factors influencing the direction of addn. of the acetoxy group to the olefinic C of the enolic species which are believed to be intermediates in these oxidns. .