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298-59-9

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Basic Information
CAS No.: 298-59-9
Name: Methylphenidate hydrochloride
Article Data: 15
Molecular Structure:
Molecular Structure of 298-59-9 (Methylphenidate hydrochloride)
Formula: C14H19NO2.HCl
Molecular Weight: 269.771
Synonyms: 2-Piperidineaceticacid, a-phenyl-, methyl ester,hydrochloride (6CI,8CI,9CI);Centedrin;Centedrine;Concerta;Medikinet;Metadate CD;Methyl a-phenyl-2-piperidineacetate hydrochloride;NSC 169868;Ritalin;Ritalin Hydrochloride;Ritalin SR;
EINECS: 206-065-3
Density: 1.07g/cm3
Melting Point: 224 - 226oC
Boiling Point: 327.6 °C at 760 mmHg
Flash Point: 152 °C
Appearance: white crystalline powder
Hazard Symbols: HarmfulXn
Risk Codes: 22-42
Safety: 22-26-36
Transport Information: UN 3249
PSA: 38.33000
LogP: 3.21610
Related products
Raw Materials
113-45-1
Downstream Products
113-45-1
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Chemistry

Molecular Formula: C14H20ClNO2
Formula Weight: 269.77
Melting Point: 224 - 226 °C
Flash Point of RITALIN HYDROCHLORIDE (298-59-9): 152 °C 
Boiling Point of RITALIN HYDROCHLORIDE (298-59-9): 327.6 °C at 760 mmHg
Vapour Pressure: 0.000199 mmHg at 25°C 
Appearance: RITALIN HYDROCHLORIDE (298-59-9) is a white crystalline powder

Uses

RITALIN HYDROCHLORIDE (298-59-9) is used as a controlled substance (stimulant).

Toxicity Data With Reference

1.   

otr-ham:emb 500 mg/L

   ENMUDM    Environmental Mutagenesis. 8 (Suppl 6)(1986),4.
2.   

orl-cld TDLo:32 mg/kg/6W-I:PSY

   BIPCBF    Biological Psychiatry. 20 (1985),1332.
3.   

orl-rat LD50:367 mg/kg

   27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,1972,264.
4.   

scu-rat LD50:170 mg/kg

   CLDND*    Compilation of LD50 Values of New Drugs .(J.R. MacDougal,Dept. of National Health and Welfare, Food and Drug Divisions,Ottawa, Ontario, Canada.: )1972,264.
5.   

orl-mus LD50:60 mg/kg

   JMCMAR    Journal of Medicinal Chemistry. 18 (1975),71.
6.   

ipr-mus LD50:167 mg/kg

   JMCMAR    Journal of Medicinal Chemistry. 14 (1971),1106.
7.   

scu-mus LD50:150 mg/kg

   JMCMAR    Journal of Medicinal Chemistry. 14 (1971),1106.
8.   

ivn-mus LDLo:40 mg/kg

   KLWOAZ    Klinische Wochenscrift. 32 (1954),445.

Safety Profile

Hazard Codes : Xn: Harmful
Risk Statements : 22: Harmful if swallowed
42: May cause sensitization by inhalation 
Safety Statements : 22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing 
RIDADR : 3249
WGK Germany : 3
RTECS : TM3850000
HazardClass : 6.1(b)
PackingGroup : III
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: toxic psychosis. Mutation data reported. Used as a central nervous system stimulant. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Specification

Storage of RITALIN HYDROCHLORIDE (298-59-9): Keep container in a cool, well-ventilated area. Keep container tightly closed.