Detail of "29858-53-5"

CAS Number:
29858-53-5
Name:
b-D-Glucopyranosiduronic acid,2-[(4-hydroxy-1-naphthalenyl)oxy]-1-[[(1-methylethyl)amino]methyl]ethyl
Molecular Structure:
Formula:
C22H29 N O9
Molecular Weight:
451.467
Synonyms:
Glucopyranosiduronicacid, 2-[(4-hydroxy-1-naphthyl)oxy]-1-[(isopropylamino)methyl]ethyl, b-D- (8CI); 4-Hydroxypropranololglucuronide
Density:
1.43g/cm³
Boiling Point:
758.6°Cat760mmHg
Flash Point:
412.6°C

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Quantitative account of propranolol metabolism in urine of normal man: Quantitative account of propranolol metabolism in urine of normal man. Walle, T.; Walle, U. K.; Olanoff, L. S. (Dep. Pharmacol., Med. Univ. South Carolina, Charleston, SC 29425, USA). Drug Metab. Dispos., 13(2), 204-9 (English) 1985. CODEN: DMDSAI. ISSN: 0090-9556. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The quant. fate of propranolol [525-66-6], including the relations among the primary metabolic pathways, i.e., glucuronidation, side-chain oxidn. and ring oxidn., was investigated. Single 80-mg oral doses of propranolol together with [3H]propranolol were administered to normal subjects. About 90% of the dose was recovered in urine. Twelve metabolites accounted for 91% of the recovered dose. Upon examn. of the metabolites derived from the primary metabolic pathways, 17% of the dose (range, 10-25%) was through glucuronidation, 41% (range, 32-50%) through side-chain oxidn., and 42% (range, 27-59%) through ring oxidn. These data show that the net elimination of propranolol is largely due to oxidative metab. The relative contribution of the primary pathways is well reflected by the 4 major propranolol metabolites, i.e.Except for chemicals metioned above, 525-66-6 is also used., propranolol glucuronide [66322-66-5], naphthoxyacetic acid [120-23-0], and the glucuronic acid conjugate [29858-53-5] and sulfate conjugate [87075-33-0] of 4'-hydroxypropranolol. .