Reference

Composition containing organic calcium and magnesium salts

Composition containing organic calcium and magnesium salts. Georgescu, Vasile; Florescu, Constantin; Dascalita, Maria (Intreprinderea de Medicamente Bucuresti, Rom.). Fr. Demande FR 2320089 4 Mar 1977, 7 pp. (French). (France). CODEN: FRXXBL. CLASS: IC: A61K031-19. PRIORITY: RO 75-83091 5 Aug 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The title compns. comprise Ca and/or Mg salts of org. acids HO2C(CH2)nRm(CHOH)xR' where n = 0-2, Rm = NHCO, CH(NH2), or 0, x = 0-4, and R' = C1-4 alkyl, CO2H, CH2OH, or CMe2CH2OH. The ratio between the salts varies from 0.5-1:1-0.5. For example, calcium gluconate [299-28-5], 215 g in water 430 g, was added to magnesium lactate [18917-93-6], 202 g in water 404 g at 20°. After 30 min the soln. was mixed with charcoal and filtered. The salts were then pptd. with org. solvents and dried.

Compatability and stability of electrolytes, vitamins and antibiotics in combination with 8% amino acids solution

Compatability and stability of electrolytes, vitamins and antibiotics in combination with 8% amino acids solution. Schuetz, David H.; King, James C. (Pharm. Serv., Roseville Commun. Hosp., Roseville, Calif., USA). Am. J. Hosp. Pharm., 35(1), 33-44 (English) 1978. CODEN: AJHPA9. ISSN: 0002-9289. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Ca gluconate [299-28-5] and K phosphate presented compatibility problems in mixts. contg. 8% amino acids and 50% dextrose, intended for parenteral nutrition, if certain concn. levels were exceeded. The order of admixt. also affected the concn. levels of these electrolytes which the mixts. will tolerate. While the addn. of multiple vitamin solns. did not produce evidence of incompatibility, there were some indications that a chem. interaction or degrdn. might be taking place. Single vitamins folic acid [59-30-3], cyanocobalamin [68-19-9] and phytonadione [84-80-0] failed to demonstrate phys. incompatibility upon admixt. or to manifest signs of chem. interaction with amino acids soln. when measured by UV. However, phytonadione should not be dild. with solns. other than NaCl (0.9%) or 5% dextrose. Cyanocobalamin usually is not recommended for i.v. use and probably should not be added to parenteral nutrition solns. because of its rapid elimination and rapid degrdn. by ascorbic acid. Although ampicillin Na [69-52-3], kanamycin sulfate [25389-94-0], cephalothin Na [58-71-9] and gentamicin sulfate [1405-41-0] were phys. compatible and microbiol. stable for 12 h in the amino acids-dextrose soln. and with certain concns. of Ca and phosphate, elevated levels of those electrolytes and vitamin mixts. could cause pptn.