CAS No.299-35-4,2(3H)-Thiazolethione,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl- Suppliers

CAS Number:
299-35-4
Name:
2(3H)-Thiazolethione,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-
Superlist Name:
Thiothiamine
Formula:
C₁₂H₁₆N₄OS₂
Molecular Structure:
Synonyms:
4-Thiazoline-2-thione,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl- (8CI);Thiamin thiothiazolone;Thiothiamin;Thiothiamine;
Molecular Weight:
296.41
EINECS:
206-077-9
Density:
1.42g/cm³
Boiling Point:
509.6 °C at 760 mmHg
Flash Point:
262 °C

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Metabolism of glutamic and: Metabolism of glutamic and .gamma.-aminobutyric acids in rat brain following the administration of large doses of thiamine and its derivatives. Koval'chuk, V. G. (Otd. Regul. 299-35-4 and 9024-58-2 are cas registry numbers. These chemicals are also mentioned in this article. Obmena Veshchestv, Grodno, USSR). Tezisy Dokl. - Konf. Beloruss. Biokhim. O-va., 2nd, 135-6. Edited by: Vecher, A. S. "Nauka i Tekhnika": Minsk, USSR. (Russian) 1974. CODEN: 33XOAH. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) In rats, thiothiamine (I) [299-35-4] and thiamine propyl disulfide-GABA [60765-72-2] inhibited the activity of glutamate decarboxylase [9024-58-2] and decreased the concn. of GABA [56-12-2] in brain tissue in 1 hr. At 3 hr after thiamine diphosphate [154-87-0] or thiamine monophosphate [532-40-1] administration the activity of .alpha.-ketoglutarate dehydrogenase [9031-02-1] was increased and that of glutamate dehydrogenase was decreased. The thiamine derivs. did not affect brain levels of alanine, asparagine, glutamic acid, aspartate transferase, or alanine transferase. .

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