Reference

The ionic dependence and steroid blockade of cyclic nucleotide-induced mitogenesis in isolated rat thymic lymphocytes

The ionic dependence and steroid blockade of cyclic nucleotide-induced mitogenesis in isolated rat thymic lymphocytes. Morgan, J. I.; Hall, A. K.; Perris, A. D. (Dep. Biol. Sci., Univ. Aston, Gosta Green/Birmingham, Engl.). J. Cyclic Nucleotide Res., 3(4), 303-14 (English) 1977. CODEN: JCNRDU. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Cyclic AMP [60-92-4] and its dibutyryl deriv. [362-74-3], as well as cyclic GMP [7665-99-8] and its dibutyryl deriv. [32266-35-6] were mitogenic in isolated rat thymic lymphocyte cultures. These compds. elicited the response over 2 distinct concn. ranges; cyclic AMP (or its dibutyryl deriv.) showed max. effect at 10-7 and 10-13 M, while cyclic GMP was maximally effective at 10-6 and 5 ′ 10-11 M. The mitotic response to the higher concns. of nucleotides was inhibited by addn. of testosterone [58-22-0] (0.1 mg/mL) or by removal of Mg2+ from the medium. At the lower nucleotide concns., the mitotic action was inhibited by addn. of estradiol [50-28-2] (0.1 mg/mL) or removal of Ca2+. The cyclic nucleotide analogs, cyclic 2'-deoxy-AMP [1157-33-1] and cyclic adenosine 2',3'-monophosphate [634-01-5] exhibited a similar biphasic mitogenic effect with ionic dependency and steroid blockade. Ro 20-1724 [29925-17-5], a cyclic nucleotide phosphodiesterase inhibitor, was also mitogenic at 10-5-10-8 M.

Inhibitory effects of cyclic AMP on vasopressin release from the rat neural lobe in vitro

Inhibitory effects of cyclic AMP on vasopressin release from the rat neural lobe in vitro. Mathison, Ron; Lederis, Karl (Fac. Med., Univ. Calgary, Calgary, Alberta, Can.). Mol. Cell. Endocrinol., 9(1), 81-9 (English) 1977. CODEN: MCEND6. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 2 The basal release of vasopressin [11000-17-2] from the isolated pituitary neural lobe of the rat decreased in the presence of exogenous cyclic AMP (I) [60-92-4], 8-bromo-cyclic AMP [23583-48-4], dibutyryl cyclic AMP [362-74-3], theophylline [58-55-9], SQ 20,009 [35838-58-5], and RO20-1724 [29925-17-5]. The concn.-related decrease in vasopressin release, in the presence of phosphodiesterase inhibitors, was accompanied by a progressive increase in I concn. in the neural lobe. The findings suggest a local modulation of vasopressin release from the neural lobes.