Detail of "29969-49-1"

Reference

Preparation of aryltetrahydropyrans and related cyclic ethers as 5-lipoxygenase inhibitors

Preparation of aryltetrahydropyrans and related cyclic ethers as 5-lipoxygenase inhibitors. Bruneau, Pierre Andre Raymond; Dowell, Robert Ian; Waterson, David (Imperial Chemical Industries PLC; ICI-Pharma S. A., UK). Eur. Pat. Appl. EP 462830 A2 27 Dec 1991, 30 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D309-04. ICS: C07D405-12; C07D309-08; A61K031-35; A61K031-47. APPLICATION: EP 91-305575 19 Jun 1991. PRIORITY: EP 90-401755 21 Jun 1990. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Ar1A1X1Ar2CR1R2R3 [I; Ar1 = (substituted) Ph, naphthyl, 9-10-membered heterocyclyl; A1 = bond, alkylene; X1 = O, S, SO, SO2, imino; Ar2 = (substituted) phenylene, pyridylene; R1 = alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, H, CHO, cyano, carbamoyl, alkyl, alkoxycarbonyl, etc.; R2R3C = (substituted) 5-7-membered O-, S-, SO-, or SO2-contg. ring], were prepd. Thus, 3-(naphth-2-ylmethoxy)bromobenzene in THF was converted to the Grignard reagent and tetrahydropyran-4-one in THF was added to give 42% coupling product, which was stirred with Lawesson's reagent in CH2Cl2 to give 18% thiol.There are some commonly used reagents with their cas registry numbers 139367-88-7 and 29969-49-1 in this article. This in DMF was treated with NaH and then MeI to give title compd. II. I inhibited antigen-induced leukotriene-dependent bronchoconstriction in guinea pigs with ED50 of 0.5-10 mg/kg i.v. .