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| CAS No.: | 29975-16-4 |
|---|---|
| Name: | Estazolam |
| Article Data: | 19 |
| Molecular Structure: | |
|
|
|
| Formula: | C16H11ClN4 |
| Molecular Weight: | 294.743 |
| Synonyms: | 4H-s-Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-phenyl- (8CI);8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;8-Chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;A 47631;Abbott 47631;Cannoc;D40TA;Esilgan;Eurodin;Julodin;NSC 290818;Nemurel;Nuctalon;ProSom;Somnatrol;4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-phenyl-; |
| EINECS: | 249-982-4 |
| Density: | 1.401 g/cm3 |
| Melting Point: | 228-229° |
| Boiling Point: | 489.936 °C at 760 mmHg |
| Flash Point: | 250.105 °C |
| Appearance: | fine, white, odorless powder |
| Hazard Symbols: |
 Xi,  T,  F
|
| Risk Codes: | 36/37/38-39/23/24/25-23/24/25-11 |
| Safety: | 36/37/39-45-36/37-16-7 |
| Transport Information: | UN 3249 |
| PSA: | 43.07000 |
| LogP: | 2.70730 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Molecular Structure of Estazolam (CAS NO.29975-16-4):
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IUPAC Name: 8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Canonical SMILES: C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4
InChI: InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
InChIKey: CDCHDCWJMGXXRH-UHFFFAOYSA-N
Molecular Weight: 294.73834 [g/mol]
Molecular Formula: C16H11ClN4
XLogP3: 1.7
H-Bond Donor: 0
H-Bond Acceptor: 3
EINECS: 249-982-4
Appearance: fine, white, odorless powder
Index of Refraction: 1.728
Molar Refractivity: 83.8 cm3
Molar Volume: 210.3 cm3
Surface Tension: 55.8 dyne/cm
Density: 1.4 g/cm3
Flash Point: 250.1 °C
Enthalpy of Vaporization: 75.64 kJ/mol
Boiling Point: 489.9 °C at 760 mmHg
Vapour Pressure: 9.55E-10 mmHg at 25 °C
Melting Point: 228.5 °C
storage temp.: 2-8 °C
Classification Code: Anti-Anxiety Agents; Anticonvulsants; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; GABA Agents; GABA modulators; Neurotransmitter Agents; Psychotropic Drugs; Reproductive Effect; Sedative-hypnotic; Tranquilizing Agents; Tumor data
Uses
Estazolam (CAS NO.29975-16-4) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Estazolam is an intermediate-acting oral benzodiazepine. It is commonly prescribed for short-term treatment of insomnia.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 593mg/kg (593mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
| mouse | LD50 | intraperitoneal | 438mg/kg (438mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: ANTIPSYCHOTIC | Japanese Journal of Pharmacology. Vol. 21, Pg. 497, 1971. |
| mouse | LD50 | oral | 600mg/kg (600mg/kg) | Collection of Czechoslovak Chemical Communications. Vol. 48, Pg. 2395, 1983. | |
| mouse | LD50 | subcutaneous | 3170mg/kg (3170mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
| rabbit | LD50 | oral | 300mg/kg (300mg/kg) | Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 32, Pg. 152, 1973. | |
| rat | LD50 | intramuscular | 868mg/kg (868mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
| rat | LD50 | intraperitoneal | 339mg/kg (339mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
| rat | LD50 | oral | 2500mg/kg (2500mg/kg) | Drugs in Japan Vol. 6, Pg. 103, 1982. | |
| rat | LD50 | subcutaneous | 3580mg/kg (3580mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. |
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by intramuscular and subcutaneous routes. Experimental reproductive effects. An hypnotic and sedative agent. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Safety Information of Estazolam (CAS NO.29975-16-4):
Hazard Codes: Xi.gif){kind=small}
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Risk Statements:
11: Highly Flammable
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
39: Danger of very serious irreversible effects
Safety Statements:
7: Keep container tightly closed
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: 3249
WGK Germany: 3
RTECS: XZ5473500
HazardClass: 6.1(b)
PackingGroup: III
Specification
Estazolam (CAS NO.29975-16-4), its Synonyms are 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl- ; 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine ; 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine ; Estazolamum ; Eurodin ; Julodin ; Nuctalon ; ProSom .