Detail of "2998-57-4"

Reference

Inhibition of T lymphocyte activation by estramustine: dose-dependent interference with IL-2 production and later proliferation events

Inhibition of T lymphocyte activation by estramustine: dose-dependent interference with IL-2 production and later proliferation events. Kalland, Terje (Dep. Anat., Univ. Lund, Lund S-223 62, Swed.). Immunopharmacology, 9(2), 65-71 (English) 1985. CODEN: IMMUDP. ISSN: 0162-3109. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Estramustine (I) [2998-57-4], a N mustard deriv. of estradiol-17b widely used for treatment of prostatic cancer, inhibited the proliferative response of mouse lymphocytes to T (concanavalin A) and B (lipopolysaccharide) cell mitogens in vitro. Concanavalin A-induced lymphoproliferation was considerably more sensitive to the antiproliferative effect of estramustine than lipopolysaccharide-stimulated proliferation. The concn. of estramustine selectively inhibiting T lymphocyte proliferation was only active when present during the first 24 h of culture and could be overcome by exogenously added interleukin 2. Estramustine directly inhibited the prodn. of interleukin 2 in concanavalin A-stimulated lymphocyte cultures without affecting the expression of interleukin 2 receptors. Thus, the preferential inhibitory effect of estramustine on mitogen-induced T lymphocyte activation is apparently mediated by interference with the prodn. or release of interleukin 2.

Interaction of estramustine phosphate with microtubule-associated proteins

Interaction of estramustine phosphate with microtubule-associated proteins. Wallin, Margareta; Deinum, Johanna; Friden, Bo (Dep. Zoophysiol., Univ. Goeteborg, Goeteborg S-400 31, Swed.). FEBS Lett., 179(2), 289-93 (English) 1985. CODEN: FEBLAL. ISSN: 0014-5793. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Estramustine (I) [2998-57-4] inhibits microtubule assembly by binding to the microtubule-assocd. proteins. Addnl. microtubule-assocd. proteins relieved the inhibition of assembly by I. 3H-labeled I bound predominantly to the microtubule-assocd. proteins. The content of the microtubule-assocd. proteins was reduced in taxol-reversed I-inhibited microtubules.