Detail of "2999-46-4"

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CAS Number:
2999-46-4
Name:
Aceticacid, 2-isocyano-, ethyl ester
Superlist Name:
Ethyl isocyanoacetate
Molecular Structure:
Formula:
C₅H₇NO₂
Molecular Weight:
113.11
Synonyms:
Aceticacid, isocyano-, ethyl ester (7CI,8CI,9CI);(Ethoxycarbonyl)methyl isonitrile;2-Ethoxy-2-oxoethyl isocyanide;Ethoxycarbonylmethyl isocyanide;Ethyl2-isocyanoacetate;Ethyl a-isocyanoacetate;Isocyanoacetic acid ethyl ester;a-Isocyanoacetic acid ethyl ester;
EINECS:
221-077-9
Density:
1.03 g/cm³
Melting Point:
194-196 °C(lit.)
Flash Point:
84 °C
Appearance:
Light yellow to brom liquid
Hazard Symbols:
Xn
Risk Codes:
20/22-20/21/22
Safety:
36/37/39-26-36/37 Details
Transport Information:
UN 2810 6.1/PG 3

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Pyridinylimidazole pharmaceuticals: Pyridinylimidazole pharmaceuticals. Lee, Thomas D. (USV Pharmaceutical Corp., USA). U.S. US 4510151 A 9 Apr 1985, 5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: ICM: A61K031-44. NCL: 514341000. APPLICATION: US 84-578918 10 Feb 1984. 2999-46-4 which is the cas registry number is also used here. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 28 Pharmaceuticals useful for congestive heart failure and hypertension treatment contained pyridinylimidazoles, I, where R1 = OH, NH2, OMe, or OEt and R2 = H, halo, or OH. Thus, 15.4 g Et isocyanoacetate [2999-46-4] was treated with 14 g 4-cyanopyridine [100-48-1] in diglyme and NaOH to give 8.3 g Et 4(5)-(4-pyridinyl)imidazole-5(4)-carboxylate (II) [96860-21-8]. II.2HCl [96892-64-7] at 0.1-10 mg/kg i.v. and at 300 mg/kg intraduodenally increased myocardial contractile force and caused a moderate decrease in blood pressure in dogs. Oral compns. could also be used. .

Derivatives of indeno[5,4-e]indazole: Derivatives of indeno[5,4-e]indazole. Nedelec, Lucien; Clausner, Andre; Van de Velde, Patrick (Roussel-UCLAF , Fr.). Fr. Demande FR 2521568 A1 19 Aug 1983, 62 pp. (French). (France).There are some reagents with their cas registry numbers 2999-46-4 and 89274-43-1 are used in this study. CODEN: FRXXBL. CLASS: IC: C07J073-00; A61K031-58. APPLICATION: FR 82-2680 18 Feb 1982. DOCUMENT TYPE: Patent CA Section: 32 (Steroids) Section cross-reference(s): 1, 2, 28 Anticholesteremic title indenoindazoles I and II [R = H, alkyl, cycloalkyl, aryl, aralkyl; R1 = Me, Et; R2 = HO, acyloxy, HOCH2CO; R3 = H, alkyl, alkenyl, alkynyl; R2R3 = (HOCH2)(HCONH)C; R4, R5 = H, HO] and their 36,4-unsatd. derivs. were prepd. via cyclocondensation of (hydroxymethylene)benzindenones with hydrazines. Thus, treating benzindenone III with MeNHNH2 in EtOH gave indenoindazole IV. Sapon of IV and then Jones oxidn. and ethynylation gave diazadinorpregnatrienyne V which, at 20 mg/kg, reduced serum cholesterol 45% in rats fed a cholesterol/cholic acid-rich diet. .