Reference

5-Bromo-5-nitro-1,3-dioxane - a new preservative for cosmetics

5-Bromo-5-nitro-1,3-dioxane - a new preservative for cosmetics. Lorenz, Peter (Firma Henkel und Cie G.m.b.H., Duesseldorf, Ger.). J. Soc. Cosmet. Chem., 28(8), 427-39 (German) 1977. CODEN: JSCCA5. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Bronidox (5-bromo-5-nitro-1,3-dioxane)(I) [30007-47-7] is recommended for use at concns. of 0.02-0.05% in aq. solns. as a preservative for shampoos and bubble bath prepns. The compd. inhibits the growth of both gram pos. and gram neg. bacteria, esp. Pseudomonas aeruginosa, as well as fungi. I showed low acute and chronic toxicity in rats and in dermatol. tests showed no irritation and no sensitization in rabbits and humans and in guinea pigs, resp.

Antioxidants - multifunctional preservatives for cosmetic and toiletry formulations?

Antioxidants - multifunctional preservatives for cosmetic and toiletry formulations?. Zeelie, J. J.; McCarthy, T. J. (Sch. Pharm., Technikon, Port Elizabeth, S. Afr.). Cosmet. Toiletries, 98(12), 51-5 (English) 1983. CODEN: CTOIDG. ISSN: 0361-4387. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Antioxidants, e.g., propyl gallate (PG) [1138-60-9] BHA [25013-16-5], TBHQ [1948-33-0], and NDGA [500-38-9], affected the activity of antimicrobial preservatives used in cosmetics, e.g., Germall 115 [39236-46-9], Kathon CG [70294-89-2], Bronidox L [30007-47-7], Bronopol [52-51-7], and Glydant [6440-58-0]. For example, TBHQ potentiated the antimicrobial activities of the preservatives against Staphylococcus aureus and Escherichia coli. Generally, the common order of increased activity regarding the effects of antioxidants on preservatives was TBHQ > PG > BHA > NDGA; TBHQ was the most sol. and NDGA was virtually insol. S. aureus, E. coli, And Candida albicans responded differently to the different antioxidants and preservatives. The Gram-pos. organism was inhibited by TBHQ but a varied effect was obsd. for Gram-neg. 1948-33-0 and 1138-60-9 are just another two chemicals used in this study. species. .