Detail of "30034-03-8"

Reference

Perfluorohydrocarbons as vehicles for administering drugs

Perfluorohydrocarbons as vehicles for administering drugs. York, Billy Murray (Alcon Laboratories, Inc., USA). Eur. Pat. Appl. EP 91313 A2 12 Oct 1983, 10 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization).Some commonly used reagents like 514-03-4 and 53-86-1 are used in this experiment. CODEN: EPXXDW. CLASS: IC: A61K009-06; A61K009-10; A61K031-02. APPLICATION: EP 83-301908 5 Apr 1983. PRIORITY: US 82-365539 5 Apr 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Perfluoro compds. and perfluorocarbons are useful as vehicles for ocular or topical administration of drugs which are unstable to an aq. medium or insol. in an aq. medium. Na cefamandole [30034-03-8] powder (1 g) was added to perfluorotributylamine [311-89-7] (200 mL) to form a 0.5% suspension. The drug, which is stable only for a few h at room temp. in an aq. soln., was stable for 5 mo at room temp. In addn., the drug did not lose any antibacterial activity in in vitro tests. In in vivo tests, the drug formulated with the perfluorocompd. was as effective as the drug in aq. vehicles. .

Desolvation kinetics of cefamandole sodium methanolate: the effect of water vapor

Desolvation kinetics of cefamandole sodium methanolate: the effect of water vapor. Pikal, M. J.; Lang, J. E.; Shah, S. (Lilly Res. Lab., Eli Lilly and Co., Indianapolis, IN 46285, USA). Int. J. Pharm., 17(2-3), 237-62 (English) 1983. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 A detailed phenomenol. study of the kinetics and thermodn. of the desolvation and solvation reactions of cefamandole sodium (I) [30034-03-8] is presented. Na I methanolate [64415-59-4] exhibits some characteristics of a nonstoichiometric solvate and has a solvation enthalpy 3.7 kcal/mol greater than the enthalpy of condensation of the solvent. The rate of vacuum demethanolation increases sharply as the crystal size decreases, is as much as a factor of 200 slower than demethanolation in the presence of water vapor, yields an apparent activation energy equal to the enthalpy of reaction, and is apparently limited by mass transfer of the MeOH through the low permeability anhydrate phase.There are some commonly used reagents with their cas registry numbers 89389-71-9 and 42540-40-9 in this article. Demethanolation in the presence of water vapor yields I hydrate [89421-83-0] which, as a 1st approxn., is a nonstoichiometric solvate. Dehydration of the hydrate is rapid. The much faster rate of conversion of methanolate to hydrate is largely a result of the extensive crystal cracking and subsequent redn. of effective crystal size which occurs during the early stages of hydrate formation. However, the hydrate phase is more permeable to MeOH than is the anhydrate phase. .